Dynamic involvement of premotor and supplementary motor areas in bimanual pinch force control
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Dynamic involvement of premotor and supplementary motor areas in bimanual pinch force control. / Karabanov, Anke Ninija; Chillemi, Gaetana; Madsen, Kristoffer Hougaard; Siebner, Hartwig Roman.
I: NeuroImage, Bind 276, 2023, s. 120203.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Dynamic involvement of premotor and supplementary motor areas in bimanual pinch force control
AU - Karabanov, Anke Ninija
AU - Chillemi, Gaetana
AU - Madsen, Kristoffer Hougaard
AU - Siebner, Hartwig Roman
N1 - Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Many activities of daily living require quick shifts between symmetric and asymmetric bimanual actions. Bimanual motor control has been mostly studied during continuous repetitive tasks, while little research has been carried out in experimental settings requiring dynamic changes in motor output generated by both hands. Here, we performed functional magnetic resonance imaging (MRI) while healthy volunteers performed a visually guided, bimanual pinch force task. This enabled us to map functional activity and connectivity of premotor and motor areas during bimanual pinch force control in different task contexts, requiring mirror-symmetric or inverse-asymmetric changes in discrete pinch force exerted with the right and left hand. The bilateral dorsal premotor cortex showed increased activity and effective coupling to the ipsilateral supplementary motor area (SMA) in the inverse-asymmetric context compared to the mirror-symmetric context of bimanual pinch force control while the SMA showed increased negative coupling to visual areas. Task-related activity of a cluster in the left caudal SMA also scaled positively with the degree of synchronous initiation of bilateral pinch force adjustments, irrespectively of the task context. The results suggest that the dorsal premotor cortex mediates increasing complexity of bimanual coordination by increasing coupling to the SMA while SMA provides feedback about motor actions to the sensory system.
AB - Many activities of daily living require quick shifts between symmetric and asymmetric bimanual actions. Bimanual motor control has been mostly studied during continuous repetitive tasks, while little research has been carried out in experimental settings requiring dynamic changes in motor output generated by both hands. Here, we performed functional magnetic resonance imaging (MRI) while healthy volunteers performed a visually guided, bimanual pinch force task. This enabled us to map functional activity and connectivity of premotor and motor areas during bimanual pinch force control in different task contexts, requiring mirror-symmetric or inverse-asymmetric changes in discrete pinch force exerted with the right and left hand. The bilateral dorsal premotor cortex showed increased activity and effective coupling to the ipsilateral supplementary motor area (SMA) in the inverse-asymmetric context compared to the mirror-symmetric context of bimanual pinch force control while the SMA showed increased negative coupling to visual areas. Task-related activity of a cluster in the left caudal SMA also scaled positively with the degree of synchronous initiation of bilateral pinch force adjustments, irrespectively of the task context. The results suggest that the dorsal premotor cortex mediates increasing complexity of bimanual coordination by increasing coupling to the SMA while SMA provides feedback about motor actions to the sensory system.
KW - Humans
KW - Psychomotor performance
KW - Motor cortex / diagnostic imaging
KW - Activities of daily living
KW - Hand
KW - Magnetic resonance imaging
KW - Functional laterality
U2 - 10.1016/j.neuroimage.2023.120203
DO - 10.1016/j.neuroimage.2023.120203
M3 - Journal article
C2 - 37271303
VL - 276
SP - 120203
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
ER -
ID: 357577246