Bacterial membrane activity of alpha-peptide/beta-peptoid chimeras: influence of amino acid composition and chain length on the activity against different bacterial strains
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Characterization and use of antimicrobial peptides (AMPs) requires that their mode of action is determined. The interaction of membrane-active peptides with their target is often established using model membranes, however, the actual permeabilization of live bacterial cells and subsequent killing is usually not tested. In this report, six a-peptide/ß-peptoid chimeras were examined for the effect of amino acid/peptoid substitutions and chain length on the membrane perturbation and subsequent killing of food-borne and clinical bacterial isolates.
Originalsprog | Engelsk |
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Tidsskrift | B M C Microbiology |
Vol/bind | 11 |
Udgave nummer | 1 |
Sider (fra-til) | 144 |
ISSN | 1471-2180 |
DOI | |
Status | Udgivet - 22 jun. 2011 |
- Det tidligere Farmaceutiske Fakultet
Forskningsområder
ID: 35102412