2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Dietary fat is thought to stimulate release of incretin hormones via activation of fatty acid receptors in the intestine. However, dietary fat (triacylglycerol) is digested to 2-monoacylglycerol and fatty acids. Activation of G protein-coupled receptor 119 (GPR119) stimulates glucagon-like peptide-1 (GLP-1) release from the intestinal L-cells. We aimed to investigate if 2-oleoyl glycerol (2OG) can activate GPR119 in vitro and stimulate GLP-1 secretion in vivo.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Clinical Endocrinology and Metabolism |
Vol/bind | 96 |
Udgave nummer | 9 |
Sider (fra-til) | E1409-17 |
ISSN | 0021-972X |
DOI | |
Status | Udgivet - 2011 |
- Det tidligere Farmaceutiske Fakultet
Forskningsområder
ID: 36082144