Oral quercetin supplementation hampers skeletal muscle adaptations in response to exercise training
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Oral quercetin supplementation hampers skeletal muscle adaptations in response to exercise training. / Casuso, R A; Martínez-López, E J; Nordsborg, Nikolai Baastrup; Hita-Contreras, F; Martínez-Romero, R; Cañuelo, A; Martínez-Amat, A.
I: Scandinavian Journal of Medicine & Science in Sports, Bind 24, Nr. 6, 2014, s. 920-927.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Oral quercetin supplementation hampers skeletal muscle adaptations in response to exercise training
AU - Casuso, R A
AU - Martínez-López, E J
AU - Nordsborg, Nikolai Baastrup
AU - Hita-Contreras, F
AU - Martínez-Romero, R
AU - Cañuelo, A
AU - Martínez-Amat, A
N1 - CURIS 2014 NEXS 354
PY - 2014
Y1 - 2014
N2 - We aimed to test exercise-induced adaptations on skeletal muscle when quercetin is supplemented. Four groups of rats were tested: quercetin sedentary, quercetin exercised, placebo sedentary, and placebo exercised. Treadmill exercise training took place 5 days a week for 6 weeks. Quercetin groups were supplemented with quercetin, via gavage, on alternate days throughout the experimental period. Sirtuin 1 (SIRT1), peroxisome proliferator-activated receptor γ coactivator-1α mRNA levels, mitochondrial DNA (mtDNA) content, and citrate synthase (CS) activity were measured on quadriceps muscle. Redox status was also quantified by measuring muscle antioxidant enzymatic activity and oxidative damage product, such as protein carbonyl content (PCC). Quercetin supplementation increased oxidative damage in both exercised and sedentary rats by inducing higher amounts of PCC (P
AB - We aimed to test exercise-induced adaptations on skeletal muscle when quercetin is supplemented. Four groups of rats were tested: quercetin sedentary, quercetin exercised, placebo sedentary, and placebo exercised. Treadmill exercise training took place 5 days a week for 6 weeks. Quercetin groups were supplemented with quercetin, via gavage, on alternate days throughout the experimental period. Sirtuin 1 (SIRT1), peroxisome proliferator-activated receptor γ coactivator-1α mRNA levels, mitochondrial DNA (mtDNA) content, and citrate synthase (CS) activity were measured on quadriceps muscle. Redox status was also quantified by measuring muscle antioxidant enzymatic activity and oxidative damage product, such as protein carbonyl content (PCC). Quercetin supplementation increased oxidative damage in both exercised and sedentary rats by inducing higher amounts of PCC (P
U2 - 10.1111/sms.12136
DO - 10.1111/sms.12136
M3 - Journal article
C2 - 24118142
VL - 24
SP - 920
EP - 927
JO - Scandinavian Journal of Medicine & Science in Sports
JF - Scandinavian Journal of Medicine & Science in Sports
SN - 0905-7188
IS - 6
ER -
ID: 61906286