Effects of nitrate supplementation in trained and untrained muscle are modest with initial high plasma nitrite levels
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Effects of nitrate supplementation in trained and untrained muscle are modest with initial high plasma nitrite levels. / Christensen, Peter Møller; Petersen, Nanna K; Friis, Signe N; Weitzberg, Eddie; Nybo, Lars.
I: Scandinavian Journal of Medicine & Science in Sports, Bind 27, Nr. 12, 2017, s. 1616-1626.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Effects of nitrate supplementation in trained and untrained muscle are modest with initial high plasma nitrite levels
AU - Christensen, Peter Møller
AU - Petersen, Nanna K
AU - Friis, Signe N
AU - Weitzberg, Eddie
AU - Nybo, Lars
N1 - CURIS 2017 NEXS 083
PY - 2017
Y1 - 2017
N2 - Nitrate (NO3(-) ) supplementation resulting in higher plasma nitrite (NO2(-) ) is reported to lower resting mean arterial blood pressure (MAP) and oxygen uptake (VO2 ) during submaximal exercise in non-athletic populations, whereas effects in general are absent in endurance trained individuals. To test whether physiological effects of NO3(-) supplementation depend on local muscular training status or cardiovascular fitness, male endurance-trained cyclists (CYC, n=9, VO2 -max: 64±3 ml/min/kg; mean±SD) and recreational active subjects serving as a control group (CON, n=8, 46±3 ml/min/kg), acutely consumed nitrate-rich beetroot-juice ([NO3(-) ] ~9 mmol) (NIT) or placebo (PLA) with assessment of resting MAP and energy expenditure during moderate intensity (~50% VO2 -max) and incremental leg cycling (LEG-ex) and arm cranking exercise (ARM-ex). NIT increased (P<0.001) resting plasma NO3(-) by ~1200% relative to PLA. Plasma NO2(-) increased ~25% (P<0.01) with a significant change only in CYC. LEG-ex VO2 (~2.60 L/min), ARM-ex VO2 (~1.14 L/min) and resting MAP (~87 mm Hg) remained unchanged for CYC and similarly for CON no changes were observed for LEG-ex VO2 (~2.03 L/min), ARM-ex VO2 (~1.06 L/min) or resting MAP (~85 mm Hg). VO2 -max was not affected by supplementation but incremental test peak power was higher (P<0.05) in LEG-ex for CYC in NIT relative to PLA (418±47 vs. 407±46 W). In both CYC and CON high initial baseline values and small increases in plasma NO2(-) after NIT may have lowered the effect of the intervention implying that muscular and cardio-vascular training status is likely not the only factors that influence the physiologic effects of NO3(-) supplementation. This article is protected by copyright. All rights reserved.
AB - Nitrate (NO3(-) ) supplementation resulting in higher plasma nitrite (NO2(-) ) is reported to lower resting mean arterial blood pressure (MAP) and oxygen uptake (VO2 ) during submaximal exercise in non-athletic populations, whereas effects in general are absent in endurance trained individuals. To test whether physiological effects of NO3(-) supplementation depend on local muscular training status or cardiovascular fitness, male endurance-trained cyclists (CYC, n=9, VO2 -max: 64±3 ml/min/kg; mean±SD) and recreational active subjects serving as a control group (CON, n=8, 46±3 ml/min/kg), acutely consumed nitrate-rich beetroot-juice ([NO3(-) ] ~9 mmol) (NIT) or placebo (PLA) with assessment of resting MAP and energy expenditure during moderate intensity (~50% VO2 -max) and incremental leg cycling (LEG-ex) and arm cranking exercise (ARM-ex). NIT increased (P<0.001) resting plasma NO3(-) by ~1200% relative to PLA. Plasma NO2(-) increased ~25% (P<0.01) with a significant change only in CYC. LEG-ex VO2 (~2.60 L/min), ARM-ex VO2 (~1.14 L/min) and resting MAP (~87 mm Hg) remained unchanged for CYC and similarly for CON no changes were observed for LEG-ex VO2 (~2.03 L/min), ARM-ex VO2 (~1.06 L/min) or resting MAP (~85 mm Hg). VO2 -max was not affected by supplementation but incremental test peak power was higher (P<0.05) in LEG-ex for CYC in NIT relative to PLA (418±47 vs. 407±46 W). In both CYC and CON high initial baseline values and small increases in plasma NO2(-) after NIT may have lowered the effect of the intervention implying that muscular and cardio-vascular training status is likely not the only factors that influence the physiologic effects of NO3(-) supplementation. This article is protected by copyright. All rights reserved.
KW - Cycling economy
KW - VO2 max
KW - NO bioavailability
KW - Blood pressure
U2 - 10.1111/sms.12848
DO - 10.1111/sms.12848
M3 - Journal article
C2 - 28165641
VL - 27
SP - 1616
EP - 1626
JO - Scandinavian Journal of Medicine & Science in Sports
JF - Scandinavian Journal of Medicine & Science in Sports
SN - 0905-7188
IS - 12
ER -
ID: 173505272