EMG-normalised kinase activation during exercise is higher in human gastrocnemius compared to soleus muscle
Research output: Contribution to journal › Journal article › Research › peer-review
In mice, certain proteins show a highly confined expression in specific muscle groups. Also, resting and exercise/contraction-induced phosphorylation responses are higher in rat skeletal muscle with low mitochondrial content compared to muscles with high mitochondrial content, possibly related to differential reactive oxygen species (ROS)-scavenging ability or resting glycogen content. To evaluate these parameters in humans, biopsies from soleus, gastrocnemius and vastus lateralis muscles were taken before and after a 45 min inclined (15%) walking exercise bout at 69% VO2(max) aimed at simultaneously activating soleus and gastrocnemius in a comparable dynamic work-pattern. Hexokinase II and GLUT4 were 46-59% and 26-38% higher (p
Original language | English |
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Journal | P L o S One |
Volume | 7 |
Issue number | 2 |
Pages (from-to) | e31054 |
Number of pages | 8 |
ISSN | 1932-6203 |
DOIs | |
Publication status | Published - 2012 |
- Electromyography, Enzyme Activation, Exercise, Glucose Transporter Type 4, Hexokinase, Humans, Muscle, Skeletal, Phosphorylation, Protein Kinases, Signal Transduction
Research areas
ID: 38565955