Voltage-dependent amplification of synaptic inputs in respiratory motoneurones
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Voltage-dependent amplification of synaptic inputs in respiratory motoneurones. / Enríquez Denton, M; Wienecke, Jacob; Zhang, Mengliang; Hultborn, Hans; Kirkwood, P A.
In: Journal of Physiology, Vol. 590, No. 13, 2012, p. 3067-3090.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Voltage-dependent amplification of synaptic inputs in respiratory motoneurones
AU - Enríquez Denton, M
AU - Wienecke, Jacob
AU - Zhang, Mengliang
AU - Hultborn, Hans
AU - Kirkwood, P A
N1 - CURIS 2012 5200 088
PY - 2012
Y1 - 2012
N2 - Key points The processes whereby various excitatory and inhibitory inputs are integrated in spinal motoneurones during naturally occurring motor acts are not well understood, largely because there are amplifying mechanisms within the motoneurone that can control the effective strengths of the inputs. Knowledge of these processes is important in understanding conditions such as motoneurone disease, or the spasticity that can follow spinal cord injury or stroke Respiration is a natural motor act that continues normally under experimental conditions, and this study investigated, for the first time, the likely amplifying processes at work in respiratory motoneurones. In phrenic motoneurones, which control the most important respiratory muscle, the diaphragm, we found that the mechanism most favoured by investigations in other motoneurones, the activation of persistent inward currents via calcium channels, appears to make a very small contribution. Instead, modulation of synaptic currents (through NMDA channels) appears to be more important.
AB - Key points The processes whereby various excitatory and inhibitory inputs are integrated in spinal motoneurones during naturally occurring motor acts are not well understood, largely because there are amplifying mechanisms within the motoneurone that can control the effective strengths of the inputs. Knowledge of these processes is important in understanding conditions such as motoneurone disease, or the spasticity that can follow spinal cord injury or stroke Respiration is a natural motor act that continues normally under experimental conditions, and this study investigated, for the first time, the likely amplifying processes at work in respiratory motoneurones. In phrenic motoneurones, which control the most important respiratory muscle, the diaphragm, we found that the mechanism most favoured by investigations in other motoneurones, the activation of persistent inward currents via calcium channels, appears to make a very small contribution. Instead, modulation of synaptic currents (through NMDA channels) appears to be more important.
U2 - 10.1113/jphysiol.2011.225789
DO - 10.1113/jphysiol.2011.225789
M3 - Journal article
C2 - 22495582
VL - 590
SP - 3067
EP - 3090
JO - The Journal of Physiology
JF - The Journal of Physiology
SN - 0022-3751
IS - 13
ER -
ID: 40323449