How plastic are human spinal cord motor circuitries?
Research output: Contribution to journal › Review › Research › peer-review
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How plastic are human spinal cord motor circuitries? / Christiansen, Lasse; Lundbye-Jensen, Jesper; Perez, Monica A; Nielsen, Jens Bo.
In: Experimental Brain Research, Vol. 235, No. 11, 2017, p. 3243-3249.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - How plastic are human spinal cord motor circuitries?
AU - Christiansen, Lasse
AU - Lundbye-Jensen, Jesper
AU - Perez, Monica A
AU - Nielsen, Jens Bo
N1 - CURIS 2017 NEXS 186
PY - 2017
Y1 - 2017
N2 - Human and animal studies have documented that neural circuitries in the spinal cord show adaptive changes caused by altered supraspinal and/or afferent input to the spinal circuitry in relation to learning, immobilization, injury and neurorehabilitation. Reversible adaptations following, e.g. the acquisition or refinement of a motor skill rely heavily on the functional integration between supraspinal and sensory inputs to the spinal cord networks. Accordingly, what is frequently conceived as a change in the spinal circuitry may be a change in either descending or afferent input or in the relative integration of these, i.e. a change in the neuronal weighting. This is evident from findings documenting only task-specific functional changes after periods of altered inputs whereas resting responses remain unaffected. In fact, the proximity of the spinal circuitry to the outer world may demand a more rigid organization compared to the highly flexible cortical circuits. The understanding of all of this is important for the planning and execution of neurorehabilitation.
AB - Human and animal studies have documented that neural circuitries in the spinal cord show adaptive changes caused by altered supraspinal and/or afferent input to the spinal circuitry in relation to learning, immobilization, injury and neurorehabilitation. Reversible adaptations following, e.g. the acquisition or refinement of a motor skill rely heavily on the functional integration between supraspinal and sensory inputs to the spinal cord networks. Accordingly, what is frequently conceived as a change in the spinal circuitry may be a change in either descending or afferent input or in the relative integration of these, i.e. a change in the neuronal weighting. This is evident from findings documenting only task-specific functional changes after periods of altered inputs whereas resting responses remain unaffected. In fact, the proximity of the spinal circuitry to the outer world may demand a more rigid organization compared to the highly flexible cortical circuits. The understanding of all of this is important for the planning and execution of neurorehabilitation.
KW - Humans
KW - Motor control
KW - Plasticity
KW - Reflexes
KW - Spinal cord
U2 - 10.1007/s00221-017-5037-x
DO - 10.1007/s00221-017-5037-x
M3 - Review
C2 - 28776155
VL - 235
SP - 3243
EP - 3249
JO - Experimental Brain Research
JF - Experimental Brain Research
SN - 0014-4819
IS - 11
ER -
ID: 181902554