Hormonal, immune, and oxidative stress responses to blood flow-restricted exercise
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Hormonal, immune, and oxidative stress responses to blood flow-restricted exercise. / Hjortshoej, M. H.; Aagaard, P.; Storgaard, C. D.; Juneja, H.; Lundbye-Jensen, J.; Magnusson, S. P.; Couppé, C.
In: Acta Physiologica, Vol. 239, No. 2, e14030, 2023.Research output: Contribution to journal › Review › Research › peer-review
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T1 - Hormonal, immune, and oxidative stress responses to blood flow-restricted exercise
AU - Hjortshoej, M. H.
AU - Aagaard, P.
AU - Storgaard, C. D.
AU - Juneja, H.
AU - Lundbye-Jensen, J.
AU - Magnusson, S. P.
AU - Couppé, C.
N1 - Publisher Copyright: © 2023 The Authors. Acta Physiologica published by John Wiley & Sons Ltd on behalf of Scandinavian Physiological Society.
PY - 2023
Y1 - 2023
N2 - Introduction: Heavy-load free-flow resistance exercise (HL-FFRE) is a widely used training modality. Recently, low-load blood-flow restricted resistance exercise (LL-BFRRE) has gained attention in both athletic and clinical settings as an alternative when conventional HL-FFRE is contraindicated or not tolerated. LL-BFRRE has been shown to result in physiological adaptations in muscle and connective tissue that are comparable to those induced by HL-FFRE. The underlying mechanisms remain unclear; however, evidence suggests that LL-BFRRE involves elevated metabolic stress compared to conventional free-flow resistance exercise (FFRE). Aim: The aim was to evaluate the initial (<10 min post-exercise), intermediate (10–20 min), and late (>30 min) hormonal, immune, and oxidative stress responses observed following acute sessions of LL-BFRRE compared to FFRE in healthy adults. Methods: A systematic literature search of randomized and non-randomized studies was conducted in PubMed, Embase, Cochrane Central, CINAHL, and SPORTDiscus. The Cochrane Risk of Bias (RoB2, ROBINS-1) and TESTEX were used to evaluate risk of bias and study quality. Data extractions were based on mean change within groups. Results: A total of 12525 hits were identified, of which 29 articles were included. LL-BFRRE demonstrated greater acute increases in growth hormone responses when compared to overall FFRE at intermediate (SMD 2.04; 95% CI 0.87, 3.22) and late (SMD 2.64; 95% CI 1.13, 4.16) post-exercise phases. LL-BFRRE also demonstrated greater increase in testosterone responses compared to late LL-FFRE. Conclusion: These results indicate that LL-BFRRE can induce increased or similar hormone and immune responses compared to LL-FFRE and HL-FFRE along with attenuated oxidative stress responses compared to HL-FFRE.
AB - Introduction: Heavy-load free-flow resistance exercise (HL-FFRE) is a widely used training modality. Recently, low-load blood-flow restricted resistance exercise (LL-BFRRE) has gained attention in both athletic and clinical settings as an alternative when conventional HL-FFRE is contraindicated or not tolerated. LL-BFRRE has been shown to result in physiological adaptations in muscle and connective tissue that are comparable to those induced by HL-FFRE. The underlying mechanisms remain unclear; however, evidence suggests that LL-BFRRE involves elevated metabolic stress compared to conventional free-flow resistance exercise (FFRE). Aim: The aim was to evaluate the initial (<10 min post-exercise), intermediate (10–20 min), and late (>30 min) hormonal, immune, and oxidative stress responses observed following acute sessions of LL-BFRRE compared to FFRE in healthy adults. Methods: A systematic literature search of randomized and non-randomized studies was conducted in PubMed, Embase, Cochrane Central, CINAHL, and SPORTDiscus. The Cochrane Risk of Bias (RoB2, ROBINS-1) and TESTEX were used to evaluate risk of bias and study quality. Data extractions were based on mean change within groups. Results: A total of 12525 hits were identified, of which 29 articles were included. LL-BFRRE demonstrated greater acute increases in growth hormone responses when compared to overall FFRE at intermediate (SMD 2.04; 95% CI 0.87, 3.22) and late (SMD 2.64; 95% CI 1.13, 4.16) post-exercise phases. LL-BFRRE also demonstrated greater increase in testosterone responses compared to late LL-FFRE. Conclusion: These results indicate that LL-BFRRE can induce increased or similar hormone and immune responses compared to LL-FFRE and HL-FFRE along with attenuated oxidative stress responses compared to HL-FFRE.
KW - blood flow restriction
KW - exercise
KW - hormone
KW - immune
KW - meta-analysis
KW - oxidative stress
U2 - 10.1111/apha.14030
DO - 10.1111/apha.14030
M3 - Review
C2 - 37732509
AN - SCOPUS:85171670438
VL - 239
JO - Acta Physiologica
JF - Acta Physiologica
SN - 1748-1708
IS - 2
M1 - e14030
ER -
ID: 371279388