Mapping different intra-hemispheric parietal-motor networks using twin coil TMS
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Mapping different intra-hemispheric parietal-motor networks using twin coil TMS. / Karabanov, Anke Ninija; Chao, Chi Chao; Paine, Rainer; Hallett, Mark.
In: Brain Stimulation, Vol. 6, No. 3, 2013, p. 384-389.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Mapping different intra-hemispheric parietal-motor networks using twin coil TMS
AU - Karabanov, Anke Ninija
AU - Chao, Chi Chao
AU - Paine, Rainer
AU - Hallett, Mark
PY - 2013
Y1 - 2013
N2 - Background: Accumulating evidence suggests anatomical and functional differences in connectivity between the anterior and posterior parts of the inferior-parietal lobule (IPL) and the frontal motor areas. Objective/ Hypothesis: This study investigates whether different intra-hemispheric parietal-motor interactions can be observed along the anterior-posterior axis of the IPL in the resting human brain. Methods: We use a twin coil transcranial magnetic stimulation technique to test intra-hemispheric interactions between three points adjacent to the intra-parietal sulcus (anterior, central, posterior) and the ipsilateral primary motor cortex (M1) at rest in both hemispheres. Results: We found that stimulation of the anterior IPL resulted in an inhibition of the ipsilateral M1 in both hemispheres. Stimulation of the central and posterior IPL resulted in a facilitatory effect on ipsilateral M1 in the left but not for the right hemisphere. Additionally we show that there is considerable inter-subject variability concerning the optimal parietal facilitatory and inhibitory position. Conclusions: The IPL has distinct inhibitory and facilitatory connections to the ipsilateral M1. Whereas inhibitory connections are observed in both hemispheres, facilitatory connections are asymmetric. These parietal-motor networks may represent the basis for the functional differences between these regions in reaching and grasping tasks and mirror the functional asymmetry observed in the motor system. From a practical point of view, we note that the inter-subject variability means that future TMS studies of the parietal area might consider a hot-spot localization similar to the procedures commonly used for M1.
AB - Background: Accumulating evidence suggests anatomical and functional differences in connectivity between the anterior and posterior parts of the inferior-parietal lobule (IPL) and the frontal motor areas. Objective/ Hypothesis: This study investigates whether different intra-hemispheric parietal-motor interactions can be observed along the anterior-posterior axis of the IPL in the resting human brain. Methods: We use a twin coil transcranial magnetic stimulation technique to test intra-hemispheric interactions between three points adjacent to the intra-parietal sulcus (anterior, central, posterior) and the ipsilateral primary motor cortex (M1) at rest in both hemispheres. Results: We found that stimulation of the anterior IPL resulted in an inhibition of the ipsilateral M1 in both hemispheres. Stimulation of the central and posterior IPL resulted in a facilitatory effect on ipsilateral M1 in the left but not for the right hemisphere. Additionally we show that there is considerable inter-subject variability concerning the optimal parietal facilitatory and inhibitory position. Conclusions: The IPL has distinct inhibitory and facilitatory connections to the ipsilateral M1. Whereas inhibitory connections are observed in both hemispheres, facilitatory connections are asymmetric. These parietal-motor networks may represent the basis for the functional differences between these regions in reaching and grasping tasks and mirror the functional asymmetry observed in the motor system. From a practical point of view, we note that the inter-subject variability means that future TMS studies of the parietal area might consider a hot-spot localization similar to the procedures commonly used for M1.
KW - Intra-hemispheric connectivity
KW - Intra-parietal sulcus
KW - Primary motor cortex
KW - Twin-coil TMS
U2 - 10.1016/j.brs.2012.08.002
DO - 10.1016/j.brs.2012.08.002
M3 - Journal article
C2 - 22939165
AN - SCOPUS:84877754930
VL - 6
SP - 384
EP - 389
JO - Brain Stimulation
JF - Brain Stimulation
SN - 1935-861X
IS - 3
ER -
ID: 218467799