Acute exercise protects newly formed motor memories against rTMS-induced interference targeting primary motor cortex
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Acute exercise protects newly formed motor memories against rTMS-induced interference targeting primary motor cortex. / Beck, Mikkel Malling; Grandjean, Marcus Udsen; Hartmand, Sander; Spedden, Meaghan Elizabeth; Christiansen, Lasse; Roig, Marc; Lundbye-Jensen, Jesper.
In: Neuroscience, Vol. 436, 2020, p. 110-121.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Acute exercise protects newly formed motor memories against rTMS-induced interference targeting primary motor cortex
AU - Beck, Mikkel Malling
AU - Grandjean, Marcus Udsen
AU - Hartmand, Sander
AU - Spedden, Meaghan Elizabeth
AU - Christiansen, Lasse
AU - Roig, Marc
AU - Lundbye-Jensen, Jesper
N1 - Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Acute cardiovascular exercise can promote motor memory consolidation following motor practice, and thus long-term retention, but the underlying mechanisms remain sparsely elucidated. Here we test the hypothesis that the positive behavioral effects of acute exercise involve the primary motor cortex and the corticospinal pathway by interfering with motor memory consolidation using non-invasive, low frequency, repetitive transcranial magnetic stimulation (rTMS). Forty-eight able-bodied, young adult male participants (mean age = 24.8 y/o) practiced a visuomotor accuracy task demanding precise and fast pinch force control. Following motor practice, participants either rested or exercised (20 min total: 3 × 3 min at 90% VO2peak) before receiving either sham rTMS or supra-threshold rTMS (115% RMT, 1 Hz) targeting the hand area of the contralateral primary motor cortex for 20 min. Retention was evaluated 24 h following motor practice, and motor memory consolidation was operationalized as overnight changes in motor performance. Low-frequency rTMS resulted in off-line decrements in motor performance compared to sham rTMS, but these were counteracted by a preceding bout of intense exercise. These findings demonstrate that a single session of exercise promotes early motor memory stabilization and protects the primary motor cortex and the corticospinal system against interference.
AB - Acute cardiovascular exercise can promote motor memory consolidation following motor practice, and thus long-term retention, but the underlying mechanisms remain sparsely elucidated. Here we test the hypothesis that the positive behavioral effects of acute exercise involve the primary motor cortex and the corticospinal pathway by interfering with motor memory consolidation using non-invasive, low frequency, repetitive transcranial magnetic stimulation (rTMS). Forty-eight able-bodied, young adult male participants (mean age = 24.8 y/o) practiced a visuomotor accuracy task demanding precise and fast pinch force control. Following motor practice, participants either rested or exercised (20 min total: 3 × 3 min at 90% VO2peak) before receiving either sham rTMS or supra-threshold rTMS (115% RMT, 1 Hz) targeting the hand area of the contralateral primary motor cortex for 20 min. Retention was evaluated 24 h following motor practice, and motor memory consolidation was operationalized as overnight changes in motor performance. Low-frequency rTMS resulted in off-line decrements in motor performance compared to sham rTMS, but these were counteracted by a preceding bout of intense exercise. These findings demonstrate that a single session of exercise promotes early motor memory stabilization and protects the primary motor cortex and the corticospinal system against interference.
KW - Faculty of Science
KW - Motor learning
KW - Skill learning
KW - Physical activity
KW - neuroplasticity
KW - Memory interference
U2 - 10.1016/j.neuroscience.2020.04.016
DO - 10.1016/j.neuroscience.2020.04.016
M3 - Journal article
C2 - 32311411
VL - 436
SP - 110
EP - 121
JO - Neuroscience
JF - Neuroscience
SN - 0306-4522
ER -
ID: 240985354