Radiosynthesis and evaluation of 11C-CIMBI-5 as a 5-HT2A receptor agonist radioligand for PET
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
PET brain imaging of the serotonin 2A (5-hydroxytryptamine 2A, or 5-HT(2A)) receptor has been widely used in clinical studies, and currently, several well-validated radiolabeled antagonist tracers are used for in vivo imaging of the cerebral 5-HT(2A) receptor. Access to 5-HT(2A) receptor agonist PET tracers would, however, enable imaging of the active, high-affinity state of receptors, which may provide a more meaningful assessment of membrane-bound receptors. In this study, we radiolabel the high-affinity 5-HT(2A) receptor agonist 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-[(11)C-OCH(3)]methoxybenzyl)ethanamine ((11)C-CIMBI-5) and investigate its potential as a PET tracer.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Nuclear Medicine |
Vol/bind | 51 |
Udgave nummer | 11 |
Sider (fra-til) | 1763-1770 |
ISSN | 0161-5505 |
DOI | |
Status | Udgivet - 1 nov. 2010 |
Bibliografisk note
Keywords: PET tracer development, agonist, porcine, serotonin receptors
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ID: 33532568