Fertilizer type affects stable isotope ratios of nitrogen in human blood plasma - results from two-year controlled agricultural field trials and a randomized crossover dietary intervention study
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Fertilizer type affects stable isotope ratios of nitrogen in human blood plasma - results from two-year controlled agricultural field trials and a randomized crossover dietary intervention study. / Mie, Axel; Novák, Vlastimil; Franko, Mikael Andersson; Bügel, Susanne Gjedsted; Laursen, Kristian Holst.
I: Journal of Agricultural and Food Chemistry, Bind 70, Nr. 11, 2022, s. 3391-3399.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Fertilizer type affects stable isotope ratios of nitrogen in human blood plasma - results from two-year controlled agricultural field trials and a randomized crossover dietary intervention study
AU - Mie, Axel
AU - Novák, Vlastimil
AU - Franko, Mikael Andersson
AU - Bügel, Susanne Gjedsted
AU - Laursen, Kristian Holst
N1 - CURIS 2022 NEXS 079
PY - 2022
Y1 - 2022
N2 - The stable nitrogen isotope ratio δ15N is used as a marker of dietary protein sources in blood. Crop fertilization strategies affect δ15N in plant foods. In a double-blinded randomized cross-over dietary intervention trial with 33 participants, we quantified the effect of fertilizer type (conventional: synthetic fertilizer and organic: animal or green manure) on δ15N in blood plasma. At study baseline, plasma δ15N was +9.34 ± 0.29‰ (mean ± standard deviation). After 12 days intervention with a diet based on crops fertilized with animal manure, plasma δ15N was shifted by +0.27 ± 0.04‰ (mean ± standard error) compared to synthetic fertilization and by +0.22 ± 0.04‰ compared to fertilization with green manure (both p < 0.0001). Accordingly, differences in the δ15N values between fertilizers are propagated to the blood plasma of human consumers. The results indicate a need to consider agricultural practices when using δ15N as a dietary biomarker.
AB - The stable nitrogen isotope ratio δ15N is used as a marker of dietary protein sources in blood. Crop fertilization strategies affect δ15N in plant foods. In a double-blinded randomized cross-over dietary intervention trial with 33 participants, we quantified the effect of fertilizer type (conventional: synthetic fertilizer and organic: animal or green manure) on δ15N in blood plasma. At study baseline, plasma δ15N was +9.34 ± 0.29‰ (mean ± standard deviation). After 12 days intervention with a diet based on crops fertilized with animal manure, plasma δ15N was shifted by +0.27 ± 0.04‰ (mean ± standard error) compared to synthetic fertilization and by +0.22 ± 0.04‰ compared to fertilization with green manure (both p < 0.0001). Accordingly, differences in the δ15N values between fertilizers are propagated to the blood plasma of human consumers. The results indicate a need to consider agricultural practices when using δ15N as a dietary biomarker.
KW - Faculty of Science
KW - Dietary protein
KW - Fertilizer type
KW - Organic food
KW - Production systems
KW - Stable nitrogen isotopes
U2 - 10.1021/acs.jafc.1c04418
DO - 10.1021/acs.jafc.1c04418
M3 - Journal article
C2 - 35263104
VL - 70
SP - 3391
EP - 3399
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
SN - 0021-8561
IS - 11
ER -
ID: 300083197