The association of serum uromodulin with allograft function and risk of urinary tract infection in kidney transplant recipients
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
The association of serum uromodulin with allograft function and risk of urinary tract infection in kidney transplant recipients. / Attari, Vahideh Ebrahimzadeh; Maddah, Arezoo; Asl, Zahra Shahveghar; Jalili, Mahsa; Ardalan, Mohammad Reza; Mokari, Saman.
I: Journal of Renal Injury Prevention, Bind 10, Nr. 1, e02, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - The association of serum uromodulin with allograft function and risk of urinary tract infection in kidney transplant recipients
AU - Attari, Vahideh Ebrahimzadeh
AU - Maddah, Arezoo
AU - Asl, Zahra Shahveghar
AU - Jalili, Mahsa
AU - Ardalan, Mohammad Reza
AU - Mokari, Saman
N1 - (Ekstern)
PY - 2021
Y1 - 2021
N2 - Introduction: There is some evidence to suggest that low levels of uromodulin in urine and serum are associated with decreased renal function and increased mortality risk.Objectives: This study is designed to measure circulating uromodulin levels and explore their relationship to urinary tract infection and renal function in kidney transplant recipients.Patients and Methods: In this cross-sectional study, 90 eligible kidney transplant recipients were evaluated 6–12 months of post-transplantation. Fasting blood samples were taken to determine the serum level of uromodulin with urea, creatinine, and other biochemical characteristics. Urine samples were taken for analysis and culture. Kidney function was estimated based on the chronic kidney disease epidemiology collaboration (CKD-EPI) creatinine equation and the modification of diet in renal disease (MDRD) equation.Results: Patients’ serum uromodulin levels were significantly correlated with their serum creatinine (P = 0.024) and estimated glomerular filtration rate by the EPI equation (eGFR-EPI, P = 0.038). There was no significant association between serum uromodulin levels and incidence of urinary tract infection of post-transplantation (P > 0.05).Conclusion: Serum and urine uromodulin levels may be regarded as the predictive indicators of renal function. However, given the lack of studies on the association between serum uromodulin levels and urinary tract infection risks in kidney transplant recipients, further research is needed to clarify uromodulin’s protective effect against urinary tract infection.
AB - Introduction: There is some evidence to suggest that low levels of uromodulin in urine and serum are associated with decreased renal function and increased mortality risk.Objectives: This study is designed to measure circulating uromodulin levels and explore their relationship to urinary tract infection and renal function in kidney transplant recipients.Patients and Methods: In this cross-sectional study, 90 eligible kidney transplant recipients were evaluated 6–12 months of post-transplantation. Fasting blood samples were taken to determine the serum level of uromodulin with urea, creatinine, and other biochemical characteristics. Urine samples were taken for analysis and culture. Kidney function was estimated based on the chronic kidney disease epidemiology collaboration (CKD-EPI) creatinine equation and the modification of diet in renal disease (MDRD) equation.Results: Patients’ serum uromodulin levels were significantly correlated with their serum creatinine (P = 0.024) and estimated glomerular filtration rate by the EPI equation (eGFR-EPI, P = 0.038). There was no significant association between serum uromodulin levels and incidence of urinary tract infection of post-transplantation (P > 0.05).Conclusion: Serum and urine uromodulin levels may be regarded as the predictive indicators of renal function. However, given the lack of studies on the association between serum uromodulin levels and urinary tract infection risks in kidney transplant recipients, further research is needed to clarify uromodulin’s protective effect against urinary tract infection.
KW - Faculty of Science
KW - Uromodulin
KW - Urinary tract infections
KW - Kidney function
KW - Kidney transplantation
KW - Chronic kidney disease
KW - Glomerular filtration rate
KW - Endstage renal disease
U2 - 10.34172/jrip.2021.02
DO - 10.34172/jrip.2021.02
M3 - Journal article
VL - 10
JO - Journal of Renal Injury Prevention
JF - Journal of Renal Injury Prevention
SN - 2345-2781
IS - 1
M1 - e02
ER -
ID: 272718041