One day of overfeeding impairs nocturnal glucose but not fatty acid homeostasis in overweight men
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One day of overfeeding impairs nocturnal glucose but not fatty acid homeostasis in overweight men. / Magkos, Faidon; Smith, Gordon I; Reeds, Dominic N; Okunade, Adewole; Patterson, Bruce W; Mittendorfer, Bettina.
I: Obesity, Bind 22, Nr. 2, 2014, s. 435-440.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - One day of overfeeding impairs nocturnal glucose but not fatty acid homeostasis in overweight men
AU - Magkos, Faidon
AU - Smith, Gordon I
AU - Reeds, Dominic N
AU - Okunade, Adewole
AU - Patterson, Bruce W
AU - Mittendorfer, Bettina
N1 - Copyright © 2013 The Obesity Society.
PY - 2014
Y1 - 2014
N2 - Objective: Overfeeding is associated with insulin resistance. Studies on animals suggest this is likely due to disruption of fatty acid metabolism and increased plasma free fatty acid (FFA) availability during the night. We tested the hypothesis that overfeeding induces insulin resistance and increases nocturnal but not daytime plasma FFA availability in human subjects.Design and methods: We measured plasma glucose, insulin, and FFA concentrations hourly for 24 h during a day of isocaloric feeding and a day of hypercaloric feeding (30% calorie excess) in 8 overweight and obese, nondiabetic men (age: 38±3 years; body mass index: 34±2 kg/m²).Results: Overfeeding had no effect on daytime plasma glucose, insulin, and FFA concentrations compared to isocaloric feeding, but increased nocturnal glucose (P = 0.007) and insulin (P = 0.003) concentrations and decreased nocturnal FFA concentration (P = 0.006). The homeostasis model assessment of insulin resistance score was ∼30% greater the morning after hypercaloric than isocaloric feeding (P = 0.040).Conclusions: One day of overfeeding has no effect on daytime plasma glucose and FFA concentrations but increases nocturnal plasma glucose and insulin concentrations, whereas nocturnal plasma FFA availability is reduced. The acute overfeeding-induced development of insulin resistant glucose metabolism therefore does not appear to be directly mediated by plasma FFA availability.
AB - Objective: Overfeeding is associated with insulin resistance. Studies on animals suggest this is likely due to disruption of fatty acid metabolism and increased plasma free fatty acid (FFA) availability during the night. We tested the hypothesis that overfeeding induces insulin resistance and increases nocturnal but not daytime plasma FFA availability in human subjects.Design and methods: We measured plasma glucose, insulin, and FFA concentrations hourly for 24 h during a day of isocaloric feeding and a day of hypercaloric feeding (30% calorie excess) in 8 overweight and obese, nondiabetic men (age: 38±3 years; body mass index: 34±2 kg/m²).Results: Overfeeding had no effect on daytime plasma glucose, insulin, and FFA concentrations compared to isocaloric feeding, but increased nocturnal glucose (P = 0.007) and insulin (P = 0.003) concentrations and decreased nocturnal FFA concentration (P = 0.006). The homeostasis model assessment of insulin resistance score was ∼30% greater the morning after hypercaloric than isocaloric feeding (P = 0.040).Conclusions: One day of overfeeding has no effect on daytime plasma glucose and FFA concentrations but increases nocturnal plasma glucose and insulin concentrations, whereas nocturnal plasma FFA availability is reduced. The acute overfeeding-induced development of insulin resistant glucose metabolism therefore does not appear to be directly mediated by plasma FFA availability.
KW - Adipose Tissue/metabolism
KW - Adult
KW - Allostasis
KW - Blood Glucose
KW - Body Mass Index
KW - Circadian Rhythm
KW - Fatty Acids, Nonesterified/blood
KW - Homeostasis
KW - Humans
KW - Hyperglycemia/etiology
KW - Hyperinsulinism/etiology
KW - Hyperphagia/blood
KW - Insulin/blood
KW - Insulin Resistance
KW - Liver/metabolism
KW - Male
KW - Muscles/metabolism
KW - Obesity/blood
KW - Overweight/blood
KW - Snacks
U2 - 10.1002/oby.20562
DO - 10.1002/oby.20562
M3 - Journal article
C2 - 23836730
VL - 22
SP - 435
EP - 440
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - 2
ER -
ID: 289966258