TY - JOUR

T1 - Estrogen deficiency after menopause does not result in male very-low-density lipoprotein metabolism phenotype

AU - Magkos, Faidon

AU - Fabbrini, Elisa

AU - Mohammed, B Selma

AU - Patterson, Bruce W

AU - Klein, Samuel

AU - Mittendorfer, Bettina

N1 - (Ekstern)

PY - 2010

Y1 - 2010

N2 - Context: Sex differences in lipid metabolism result in a less proatherogenic plasma lipid profile in premenopausal women than men. The mechanisms responsible for this are unclear but are thought to be related to differences in the sex hormone milieu in men and women.Objective: Our objective was to evaluate the effect of endogenous sex hormones on very-low-density lipoprotein (VLDL) triglyceride (TG) and apolipoprotein B-100 (apoB-100) metabolism. Experimental design and main outcome measures: We measured basal VLDL-TG and VLDL-apoB-100 concentrations and kinetics by using stable isotope-labeled tracers.Setting and participants: Eight premenopausal women [age, 43 + or - 8 yr; body mass index (BMI), 35 + or - 4 kg/m(2); mean + or - sd], eight postmenopausal women (age, 55 + or - 4 yr; BMI, 34 + or - 4 kg/m(2)), and eight men (age, 41 + or - 13 yr; BMI, 34 + or - 4 kg/m(2)) were studied at Washington University School of Medicine, St. Louis, MO.Results: VLDL-TG secretion rate was approximately double (P < 0.05) in postmenopausal women and men compared with premenopausal women but not different in postmenopausal women and men. The secretion rate of VLDL-apoB-100 was not different in pre- and postmenopausal women but was greater (P < 0.05) in men than in women.Conclusions: Endogenous ovarian sex steroids are responsible for sexual dimorphism in VLDL-TG secretion, whereas VLDL-apoB-100 secretion is not regulated by female reproductive hormones.

AB - Context: Sex differences in lipid metabolism result in a less proatherogenic plasma lipid profile in premenopausal women than men. The mechanisms responsible for this are unclear but are thought to be related to differences in the sex hormone milieu in men and women.Objective: Our objective was to evaluate the effect of endogenous sex hormones on very-low-density lipoprotein (VLDL) triglyceride (TG) and apolipoprotein B-100 (apoB-100) metabolism. Experimental design and main outcome measures: We measured basal VLDL-TG and VLDL-apoB-100 concentrations and kinetics by using stable isotope-labeled tracers.Setting and participants: Eight premenopausal women [age, 43 + or - 8 yr; body mass index (BMI), 35 + or - 4 kg/m(2); mean + or - sd], eight postmenopausal women (age, 55 + or - 4 yr; BMI, 34 + or - 4 kg/m(2)), and eight men (age, 41 + or - 13 yr; BMI, 34 + or - 4 kg/m(2)) were studied at Washington University School of Medicine, St. Louis, MO.Results: VLDL-TG secretion rate was approximately double (P < 0.05) in postmenopausal women and men compared with premenopausal women but not different in postmenopausal women and men. The secretion rate of VLDL-apoB-100 was not different in pre- and postmenopausal women but was greater (P < 0.05) in men than in women.Conclusions: Endogenous ovarian sex steroids are responsible for sexual dimorphism in VLDL-TG secretion, whereas VLDL-apoB-100 secretion is not regulated by female reproductive hormones.

KW - Adult

KW - Analysis of Variance

KW - Apolipoprotein B-100/metabolism

KW - Body Composition/physiology

KW - Enzyme-Linked Immunosorbent Assay

KW - Estradiol/blood

KW - Estrogens/deficiency

KW - Female

KW - Follicle Stimulating Hormone/blood

KW - Humans

KW - Insulin Resistance/physiology

KW - Lipoproteins, VLDL/metabolism

KW - Male

KW - Middle Aged

KW - Postmenopause/metabolism

KW - Premenopause/metabolism

KW - Progesterone/blood

KW - Sex Factors

KW - Testosterone/blood

KW - Triglycerides/metabolism

U2 - 10.1210/jc.2010-0341

DO - 10.1210/jc.2010-0341

M3 - Journal article

C2 - 20444912

VL - 95

SP - 3377

EP - 3384

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 7

ER -