Are dietary proteins the key to successful body weight management? A systematic review and meta-analysis of studies assessing body weight outcomes after interventions with increased dietary protein
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Are dietary proteins the key to successful body weight management? A systematic review and meta-analysis of studies assessing body weight outcomes after interventions with increased dietary protein. / Hansen, Thea Toft; Astrup, Arne; Sjödin, Anders.
I: Nutrients, Bind 13, Nr. 9, 3193, 2021.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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T1 - Are dietary proteins the key to successful body weight management? A systematic review and meta-analysis of studies assessing body weight outcomes after interventions with increased dietary protein
AU - Hansen, Thea Toft
AU - Astrup, Arne
AU - Sjödin, Anders
N1 - CURIS 2021 NEXS 298
PY - 2021
Y1 - 2021
N2 - The primary aim was to systematically review the current evidence investigating if dietary interventions rich in protein lead to improved body weight management in adults with excessive body weight. The secondary aim was to investigate potential modifying effects of phenotyping. A systematic literature search in PubMed, Web of Science, and Cochrane Library identified 375randomized controlled trials with 43 unique trials meeting the inclusion criteria. The Cochrane collaboration tool was used for a thorough risk of bias assessment. Based on 37 studies evaluating effects of dietary protein on body weight, the participants with increased protein intake (ranging from 18–59 energy percentage [E%]) were found to reduce body weight by 1.6 (1.2; 2.0) kg (mean [95% confidence interval]) compared to controls (isocaloric interventions with energy reduction introduced in certain studies). Individuals with prediabetes were found to benefit more from a diet high in protein compared to individuals with normoglycemia, as did individuals without the obesity risk allele (AA genotype) compared to individuals with the obesity risk alleles (AG and GGgenotypes). Thus, diets rich in protein would seem to have a moderate beneficial effect on body weight management.
AB - The primary aim was to systematically review the current evidence investigating if dietary interventions rich in protein lead to improved body weight management in adults with excessive body weight. The secondary aim was to investigate potential modifying effects of phenotyping. A systematic literature search in PubMed, Web of Science, and Cochrane Library identified 375randomized controlled trials with 43 unique trials meeting the inclusion criteria. The Cochrane collaboration tool was used for a thorough risk of bias assessment. Based on 37 studies evaluating effects of dietary protein on body weight, the participants with increased protein intake (ranging from 18–59 energy percentage [E%]) were found to reduce body weight by 1.6 (1.2; 2.0) kg (mean [95% confidence interval]) compared to controls (isocaloric interventions with energy reduction introduced in certain studies). Individuals with prediabetes were found to benefit more from a diet high in protein compared to individuals with normoglycemia, as did individuals without the obesity risk allele (AA genotype) compared to individuals with the obesity risk alleles (AG and GGgenotypes). Thus, diets rich in protein would seem to have a moderate beneficial effect on body weight management.
KW - Faculty of Science
KW - Appetite
KW - Obesity
KW - Overweight
KW - Satiety
KW - Weight loss
UR - https://doi.org/10.3390/nu13093193
U2 - 10.3390/nu13093193
DO - 10.3390/nu13093193
M3 - Review
C2 - 34579069
VL - 13
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 9
M1 - 3193
ER -
ID: 280110769