Oxidative stress response after laparoscopic versus conventional sigmoid resection: a randomized, double-blind clinical trial
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Oxidative stress response after laparoscopic versus conventional sigmoid resection : a randomized, double-blind clinical trial. / Madsen, Michael Tvilling; Kücükakin, Bülent; Lykkesfeldt, Jens; Rosenberg, Jacob; Gögenur, Ismail.
I: Surgical Laparoscopy, Endoscopy and Percutaneous Techniques, Bind 22, Nr. 3, 2012, s. 215-219.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Oxidative stress response after laparoscopic versus conventional sigmoid resection
T2 - a randomized, double-blind clinical trial
AU - Madsen, Michael Tvilling
AU - Kücükakin, Bülent
AU - Lykkesfeldt, Jens
AU - Rosenberg, Jacob
AU - Gögenur, Ismail
PY - 2012
Y1 - 2012
N2 - Surgery is accompanied by a surgical stress response, which results in increased morbidity and mortality. Oxidative stress is a part of the surgical stress response. Minimally invasive laparoscopic surgery may result in reduced oxidative stress compared with open surgery. Nineteen patients scheduled for sigmoid resection were randomly allocated to open or laparoscopic sigmoid resection in a double-blind, prospective clinical trial. Three biochemical markers of oxidative stress (malondialdehyde, ascorbic acid, and dehydroascorbic acid) were measured at 6 different time points (preoperatively, 1 h, 6 h, 24 h, 48 h, and 72 h postoperatively). There were no statistical significant differences between laparoscopic and open surgery for any of the 3 oxidative stress parameters. Malondialdehyde was reduced 1 hour postoperatively (P
AB - Surgery is accompanied by a surgical stress response, which results in increased morbidity and mortality. Oxidative stress is a part of the surgical stress response. Minimally invasive laparoscopic surgery may result in reduced oxidative stress compared with open surgery. Nineteen patients scheduled for sigmoid resection were randomly allocated to open or laparoscopic sigmoid resection in a double-blind, prospective clinical trial. Three biochemical markers of oxidative stress (malondialdehyde, ascorbic acid, and dehydroascorbic acid) were measured at 6 different time points (preoperatively, 1 h, 6 h, 24 h, 48 h, and 72 h postoperatively). There were no statistical significant differences between laparoscopic and open surgery for any of the 3 oxidative stress parameters. Malondialdehyde was reduced 1 hour postoperatively (P
KW - Former LIFE faculty
KW - sigmoid resection
KW - oxidative stress response
KW - lipid peroxidation
KW - antioxidants
U2 - 10.1097/SLE.0b013e31824ddda9
DO - 10.1097/SLE.0b013e31824ddda9
M3 - Journal article
C2 - 22678316
VL - 22
SP - 215
EP - 219
JO - Surgical Laparoscopy and Endoscopy
JF - Surgical Laparoscopy and Endoscopy
SN - 1530-4515
IS - 3
ER -
ID: 40191970