Vitamin D supplementation and increased dairy protein intake do not affect muscle strength or physical function in healthy 6–8-year-old children: the D-pro randomized trial
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Vitamin D supplementation and increased dairy protein intake do not affect muscle strength or physical function in healthy 6–8-year-old children: the D-pro randomized trial. / Thams, Line; Hvid, Lars G; Stounbjerg, Nanna Groth; Brønd, Jan Christian; Mølgaard, Christian; Damsgaard, Camilla Trab; Hansen, Mette.
I: European Journal of Nutrition, Bind 61, Nr. 7, 2022, s. 3613-3623.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Vitamin D supplementation and increased dairy protein intake do not affect muscle strength or physical function in healthy 6–8-year-old children: the D-pro randomized trial
AU - Thams, Line
AU - Hvid, Lars G
AU - Stounbjerg, Nanna Groth
AU - Brønd, Jan Christian
AU - Mølgaard, Christian
AU - Damsgaard, Camilla Trab
AU - Hansen, Mette
N1 - CURIS 2022 NEXS 143
PY - 2022
Y1 - 2022
N2 - Purpose: To investigate separate and combined effects of vitamin D supplementation during the extended winter and increased dairy protein intake on muscle strength and physical function in children, and furthermore to explore potential sex differences.Methods: In a 2×2-factorial, randomized winter trial, 183 healthy, 6–8-year-old children received blinded tablets with 20 µg/day vitamin D3 or placebo, and substituted 260 g/day dairy with yogurts with high (HP, 10 g protein/100 g) or normal protein content (NP, 3.5 g protein/100 g) for 24 weeks during winter at 55° N. We measured maximal isometric handgrip and leg press strength, and physical function by jump tests and a 30 s sit-to-stand test. Physical activity was measured by 7-day accelerometry.Results: Baseline (mean±SD) serum 25-hydroxyvitamin D was 80.8±17.2 nmol/L, which increased to 88.7±17.6 nmol/L with vitamin D supplementation and decreased to 48.4±19.2 nmol/L with placebo. Baseline protein intake was 15.5±2.4 E%, which increased to 18.4±3.4 E% with HP and was unchanged with NP. We found no separate or combined effects of vitamin D supplementation and/or increased dairy protein intake on muscle strength or physical function (all P>0.20). There was an interaction on the sit-to-stand test (Pvitamin×yogurt=0.02), which however disappeared after adjusting for physical activity (P=0.16). Further, vitamin D supplementation increased leg press strength relatively more in girls compared to boys (mean [95% CI] 158 [17, 299] N; Pvitamin×sex=0.047).Conclusion: Overall, vitamin D and dairy protein supplementation during the extended winter did not affect muscle strength or physical function in healthy children. Potential sex differences of vitamin D supplementation should be investigated further.Registered at clinicaltrials.gov: NCT0395673.
AB - Purpose: To investigate separate and combined effects of vitamin D supplementation during the extended winter and increased dairy protein intake on muscle strength and physical function in children, and furthermore to explore potential sex differences.Methods: In a 2×2-factorial, randomized winter trial, 183 healthy, 6–8-year-old children received blinded tablets with 20 µg/day vitamin D3 or placebo, and substituted 260 g/day dairy with yogurts with high (HP, 10 g protein/100 g) or normal protein content (NP, 3.5 g protein/100 g) for 24 weeks during winter at 55° N. We measured maximal isometric handgrip and leg press strength, and physical function by jump tests and a 30 s sit-to-stand test. Physical activity was measured by 7-day accelerometry.Results: Baseline (mean±SD) serum 25-hydroxyvitamin D was 80.8±17.2 nmol/L, which increased to 88.7±17.6 nmol/L with vitamin D supplementation and decreased to 48.4±19.2 nmol/L with placebo. Baseline protein intake was 15.5±2.4 E%, which increased to 18.4±3.4 E% with HP and was unchanged with NP. We found no separate or combined effects of vitamin D supplementation and/or increased dairy protein intake on muscle strength or physical function (all P>0.20). There was an interaction on the sit-to-stand test (Pvitamin×yogurt=0.02), which however disappeared after adjusting for physical activity (P=0.16). Further, vitamin D supplementation increased leg press strength relatively more in girls compared to boys (mean [95% CI] 158 [17, 299] N; Pvitamin×sex=0.047).Conclusion: Overall, vitamin D and dairy protein supplementation during the extended winter did not affect muscle strength or physical function in healthy children. Potential sex differences of vitamin D supplementation should be investigated further.Registered at clinicaltrials.gov: NCT0395673.
KW - Faculty of Science
KW - Pediatric
KW - Muscle function
KW - Dietary supplements
KW - Physical performance
KW - Diet
KW - Milk protein
U2 - 10.1007/s00394-022-02912-0
DO - 10.1007/s00394-022-02912-0
M3 - Journal article
C2 - 35643873
VL - 61
SP - 3613
EP - 3623
JO - European Journal of Nutrition
JF - European Journal of Nutrition
SN - 1436-6207
IS - 7
ER -
ID: 308372228