Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, randomized, placebo-controlled study

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Standard

Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, randomized, placebo-controlled study. / Aronis, Konstantinos N; Vamvini, Maria T; Chamberland, John P; Sweeney, Laura L; Brennan, Aoife M; Magkos, Faidon; Mantzoros, Christos S.

I: Metabolism, Bind 61, Nr. 4, 2012, s. 577-582.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Aronis, KN, Vamvini, MT, Chamberland, JP, Sweeney, LL, Brennan, AM, Magkos, F & Mantzoros, CS 2012, 'Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, randomized, placebo-controlled study', Metabolism, bind 61, nr. 4, s. 577-582. https://doi.org/10.1016/j.metabol.2011.09.008

APA

Aronis, K. N., Vamvini, M. T., Chamberland, J. P., Sweeney, L. L., Brennan, A. M., Magkos, F., & Mantzoros, C. S. (2012). Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, randomized, placebo-controlled study. Metabolism, 61(4), 577-582. https://doi.org/10.1016/j.metabol.2011.09.008

Vancouver

Aronis KN, Vamvini MT, Chamberland JP, Sweeney LL, Brennan AM, Magkos F o.a. Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, randomized, placebo-controlled study. Metabolism. 2012;61(4):577-582. https://doi.org/10.1016/j.metabol.2011.09.008

Author

Aronis, Konstantinos N ; Vamvini, Maria T ; Chamberland, John P ; Sweeney, Laura L ; Brennan, Aoife M ; Magkos, Faidon ; Mantzoros, Christos S. / Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, randomized, placebo-controlled study. I: Metabolism. 2012 ; Bind 61, Nr. 4. s. 577-582.

Bibtex

@article{6356352f71144056beeb8c83da983b04,

title = "Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, randomized, placebo-controlled study",

abstract = "Long-term consumption of walnuts is associated with lower cardiovascular disease risk in epidemiological studies, possibly through improvements in lipid profile and endothelial function. It remains to be elucidated how soon after initiation of walnut consumption beneficial effects on lipid profile and biomarkers of inflammation or vascular injury can be observed. Fifteen obese subjects (9 men and 6 women; age, 58 ± 2.5 years; body mass index, 36.6 ± 1.7 kg/m(2)) with the metabolic syndrome participated as inpatients in a randomized, double-blinded, placebo-controlled crossover study involving short-term placebo or walnut-enriched diet (48 g/d for 4 days). Apolipoproteins and markers of inflammation and vascular injury were measured before and after consumption of the experimental diets. Consumption of walnuts was associated with a statistically significant increase in serum apolipoprotein A concentrations (P = .03), but did not affect circulating levels of fetuin A, resistin, C-reactive protein, serum amyloid A, soluble intercellular adhesion molecules 1 and 3, soluble vascular cell adhesion protein 1, interleukins 6 and 8, tumor necrosis factor α, E-selectin, P-selectin, and thrombomodulin. Four days of walnut consumption (48 g/d) leads to mild increases in apolipoprotein A concentrations, changes that may precede and lead to the beneficial effects of walnuts on lipid profile in obese subjects with the metabolic syndrome.",

keywords = "Adiponectin/blood, Apolipoprotein A-I/blood, C-Reactive Protein/metabolism, Cell Adhesion Molecules/blood, Cross-Over Studies, Double-Blind Method, Female, Humans, Interleukins/blood, Juglans, Male, Metabolic Syndrome/blood, Middle Aged, Obesity/blood, Resistin/blood, Selectins/blood, Serum Amyloid A Protein/metabolism, Statistics, Nonparametric, Thrombomodulin/blood, Tumor Necrosis Factor-alpha/blood, Vascular Cell Adhesion Molecule-1/blood, alpha-2-HS-Glycoprotein/metabolism",

author = "Aronis, {Konstantinos N} and Vamvini, {Maria T} and Chamberland, {John P} and Sweeney, {Laura L} and Brennan, {Aoife M} and Faidon Magkos and Mantzoros, {Christos S}",

year = "2012",

doi = "10.1016/j.metabol.2011.09.008",

language = "English",

volume = "61",

pages = "577--582",

journal = "Metabolism",

issn = "0026-0495",

publisher = "Elsevier",

number = "4",

}

RIS

TY - JOUR

T1 - Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, randomized, placebo-controlled study

AU - Aronis, Konstantinos N

AU - Vamvini, Maria T

AU - Chamberland, John P

AU - Sweeney, Laura L

AU - Brennan, Aoife M

AU - Magkos, Faidon

AU - Mantzoros, Christos S

PY - 2012

Y1 - 2012

N2 - Long-term consumption of walnuts is associated with lower cardiovascular disease risk in epidemiological studies, possibly through improvements in lipid profile and endothelial function. It remains to be elucidated how soon after initiation of walnut consumption beneficial effects on lipid profile and biomarkers of inflammation or vascular injury can be observed. Fifteen obese subjects (9 men and 6 women; age, 58 ± 2.5 years; body mass index, 36.6 ± 1.7 kg/m(2)) with the metabolic syndrome participated as inpatients in a randomized, double-blinded, placebo-controlled crossover study involving short-term placebo or walnut-enriched diet (48 g/d for 4 days). Apolipoproteins and markers of inflammation and vascular injury were measured before and after consumption of the experimental diets. Consumption of walnuts was associated with a statistically significant increase in serum apolipoprotein A concentrations (P = .03), but did not affect circulating levels of fetuin A, resistin, C-reactive protein, serum amyloid A, soluble intercellular adhesion molecules 1 and 3, soluble vascular cell adhesion protein 1, interleukins 6 and 8, tumor necrosis factor α, E-selectin, P-selectin, and thrombomodulin. Four days of walnut consumption (48 g/d) leads to mild increases in apolipoprotein A concentrations, changes that may precede and lead to the beneficial effects of walnuts on lipid profile in obese subjects with the metabolic syndrome.

AB - Long-term consumption of walnuts is associated with lower cardiovascular disease risk in epidemiological studies, possibly through improvements in lipid profile and endothelial function. It remains to be elucidated how soon after initiation of walnut consumption beneficial effects on lipid profile and biomarkers of inflammation or vascular injury can be observed. Fifteen obese subjects (9 men and 6 women; age, 58 ± 2.5 years; body mass index, 36.6 ± 1.7 kg/m(2)) with the metabolic syndrome participated as inpatients in a randomized, double-blinded, placebo-controlled crossover study involving short-term placebo or walnut-enriched diet (48 g/d for 4 days). Apolipoproteins and markers of inflammation and vascular injury were measured before and after consumption of the experimental diets. Consumption of walnuts was associated with a statistically significant increase in serum apolipoprotein A concentrations (P = .03), but did not affect circulating levels of fetuin A, resistin, C-reactive protein, serum amyloid A, soluble intercellular adhesion molecules 1 and 3, soluble vascular cell adhesion protein 1, interleukins 6 and 8, tumor necrosis factor α, E-selectin, P-selectin, and thrombomodulin. Four days of walnut consumption (48 g/d) leads to mild increases in apolipoprotein A concentrations, changes that may precede and lead to the beneficial effects of walnuts on lipid profile in obese subjects with the metabolic syndrome.

KW - Adiponectin/blood

KW - Apolipoprotein A-I/blood

KW - C-Reactive Protein/metabolism

KW - Cell Adhesion Molecules/blood

KW - Cross-Over Studies

KW - Double-Blind Method

KW - Female

KW - Humans

KW - Interleukins/blood

KW - Juglans

KW - Male

KW - Metabolic Syndrome/blood

KW - Middle Aged

KW - Obesity/blood

KW - Resistin/blood

KW - Selectins/blood

KW - Serum Amyloid A Protein/metabolism

KW - Statistics, Nonparametric

KW - Thrombomodulin/blood

KW - Tumor Necrosis Factor-alpha/blood

KW - Vascular Cell Adhesion Molecule-1/blood

KW - alpha-2-HS-Glycoprotein/metabolism

U2 - 10.1016/j.metabol.2011.09.008

DO - 10.1016/j.metabol.2011.09.008

M3 - Journal article

C2 - 22075273

VL - 61

SP - 577

EP - 582

JO - Metabolism

JF - Metabolism

SN - 0026-0495

IS - 4

ER -

ID: 290036168

Institut for Idræt og Ernæring