Effects of leptin and adiponectin on pancreatic β-cell function
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Effects of leptin and adiponectin on pancreatic β-cell function. / Lee, Yong-ho; Magkos, Faidon; Mantzoros, Christos S; Kang, Eun Seok.
I: Metabolism, Bind 60, Nr. 12, 2011, s. 1664-1672.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Effects of leptin and adiponectin on pancreatic β-cell function
AU - Lee, Yong-ho
AU - Magkos, Faidon
AU - Mantzoros, Christos S
AU - Kang, Eun Seok
N1 - Copyright © 2011 Elsevier Inc. All rights reserved.
PY - 2011
Y1 - 2011
N2 - Leptin and adiponectin are hormones secreted from adipocytes that have important roles in metabolism and energy homeostasis. This review evaluates the effects of leptin and adiponectin on β-cell function by analyzing and compiling results from human clinical trials and epidemiologic studies as well as in vitro and in vivo experiments. Leptin has been shown to inhibit ectopic fat accumulation and thereby prevent β-cell dysfunction and protect the β-cell from cytokine- and fatty acid-induced apoptosis. However, leptin suppresses insulin gene expression and secretion as well as glucose transport into the β-cell. Adiponectin stimulates insulin secretion by enhancing exocytosis of insulin granules and upregulating the expression of the insulin gene; however, this effect depends on the prevailing glucose concentration and status of insulin resistance. In addition, adiponectin has antiapoptotic properties in β-cells. Available evidence concerning the role of these adipokines on insulin secretion, insulin gene expression, and apoptosis is not always entirely consistent; and many fundamental questions remain to be answered by future studies.
AB - Leptin and adiponectin are hormones secreted from adipocytes that have important roles in metabolism and energy homeostasis. This review evaluates the effects of leptin and adiponectin on β-cell function by analyzing and compiling results from human clinical trials and epidemiologic studies as well as in vitro and in vivo experiments. Leptin has been shown to inhibit ectopic fat accumulation and thereby prevent β-cell dysfunction and protect the β-cell from cytokine- and fatty acid-induced apoptosis. However, leptin suppresses insulin gene expression and secretion as well as glucose transport into the β-cell. Adiponectin stimulates insulin secretion by enhancing exocytosis of insulin granules and upregulating the expression of the insulin gene; however, this effect depends on the prevailing glucose concentration and status of insulin resistance. In addition, adiponectin has antiapoptotic properties in β-cells. Available evidence concerning the role of these adipokines on insulin secretion, insulin gene expression, and apoptosis is not always entirely consistent; and many fundamental questions remain to be answered by future studies.
KW - Adiponectin/metabolism
KW - Animals
KW - Apoptosis/drug effects
KW - Clinical Trials as Topic
KW - Epidemiologic Studies
KW - Gene Expression Regulation/drug effects
KW - Humans
KW - Insulin/metabolism
KW - Insulin Resistance
KW - Insulin Secretion
KW - Insulin-Secreting Cells/drug effects
KW - Leptin/metabolism
U2 - 10.1016/j.metabol.2011.04.008
DO - 10.1016/j.metabol.2011.04.008
M3 - Review
C2 - 21632069
VL - 60
SP - 1664
EP - 1672
JO - Metabolism
JF - Metabolism
SN - 0026-0495
IS - 12
ER -
ID: 290039407