Effect of weight gain and weight loss on in vivo colonocyte proliferation rate in people with obesity
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Effect of weight gain and weight loss on in vivo colonocyte proliferation rate in people with obesity. / Magkos, Faidon; Sullivan, Shelby; Fitch, Mark; Smith, Gordon; Fabbrini, Elisa; Mittendorfer, Bettina; Hellerstein, Marc; Klein, Samuel.
I: Obesity, Bind 25, Nr. Suppl 2, 2017, s. S81-S86.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Effect of weight gain and weight loss on in vivo colonocyte proliferation rate in people with obesity
AU - Magkos, Faidon
AU - Sullivan, Shelby
AU - Fitch, Mark
AU - Smith, Gordon
AU - Fabbrini, Elisa
AU - Mittendorfer, Bettina
AU - Hellerstein, Marc
AU - Klein, Samuel
N1 - © 2017 The Obesity Society.
PY - 2017
Y1 - 2017
N2 - Objective: To evaluate the effects of diet-induced changes in energy balance and body weight on in vivo colonocyte fractional proliferation rates (FPR) in people with obesity.Methods: In vivo colonocyte FPR was assessed in 31 men and women with obesity (BMI: 35.4 ± 4.0 kg/m2 , age: 52.6 ± 8.9 years) before and after diet-induced weight loss, weight gain, or weight maintenance. Subjects ingested aliquots of 2H2O (heavy water) daily for 4 to 7 days, followed by flexible sigmoidoscopy with colon biopsies to assess the incorporation of 2 H into the DNA of dividing colonocytes.Results: Colonocyte FPR averaged 12.7% ± 3.8% per day and correlated directly with intra-abdominal adipose tissue (IAAT) volume (r = 0.364, P = 0.044). Colonocyte FPR decreased in the weight loss group, did not change in the weight maintenance group, and increased in the weight gain group. The change in colonocyte FPR correlated directly with the percent change in body weight (r = 0.409, P = 0.028) and IAAT volume (r = 0.598, P = 0.001).Conclusions: A high-calorie diet and weight gain increase, whereas a low-calorie diet and weight loss decrease, in vivo colonocyte proliferation rate in people with obesity. These results suggest that changes in energy balance influence the risk of developing colon cancer in people with obesity by regulating colonic mucosal growth rates.
AB - Objective: To evaluate the effects of diet-induced changes in energy balance and body weight on in vivo colonocyte fractional proliferation rates (FPR) in people with obesity.Methods: In vivo colonocyte FPR was assessed in 31 men and women with obesity (BMI: 35.4 ± 4.0 kg/m2 , age: 52.6 ± 8.9 years) before and after diet-induced weight loss, weight gain, or weight maintenance. Subjects ingested aliquots of 2H2O (heavy water) daily for 4 to 7 days, followed by flexible sigmoidoscopy with colon biopsies to assess the incorporation of 2 H into the DNA of dividing colonocytes.Results: Colonocyte FPR averaged 12.7% ± 3.8% per day and correlated directly with intra-abdominal adipose tissue (IAAT) volume (r = 0.364, P = 0.044). Colonocyte FPR decreased in the weight loss group, did not change in the weight maintenance group, and increased in the weight gain group. The change in colonocyte FPR correlated directly with the percent change in body weight (r = 0.409, P = 0.028) and IAAT volume (r = 0.598, P = 0.001).Conclusions: A high-calorie diet and weight gain increase, whereas a low-calorie diet and weight loss decrease, in vivo colonocyte proliferation rate in people with obesity. These results suggest that changes in energy balance influence the risk of developing colon cancer in people with obesity by regulating colonic mucosal growth rates.
KW - Biopsy
KW - Body Composition
KW - Body Weight
KW - Cell Proliferation
KW - Colon/cytology
KW - Colonic Neoplasms/etiology
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Obesity, Abdominal/complications
KW - Risk
KW - Weight Gain
KW - Weight Loss
U2 - 10.1002/oby.21983
DO - 10.1002/oby.21983
M3 - Journal article
C2 - 29086514
VL - 25
SP - S81-S86
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - Suppl 2
ER -
ID: 210874222