IgA against gut-derived endotoxins: Does it contribute to suppression of hepatic inflammation in alcohol-induced liver disease?

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Standard

IgA against gut-derived endotoxins: Does it contribute to suppression of hepatic inflammation in alcohol-induced liver disease? / Parlesak, Alexandr; Schäfer, Christian; Bode, Christiane.

I: Digestive Diseases and Sciences, Bind 47, Nr. 4, 2002, s. 760-766.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Parlesak, A, Schäfer, C & Bode, C 2002, 'IgA against gut-derived endotoxins: Does it contribute to suppression of hepatic inflammation in alcohol-induced liver disease?', Digestive Diseases and Sciences, bind 47, nr. 4, s. 760-766. https://doi.org/10.1023/A:1014783815433

APA

Parlesak, A., Schäfer, C., & Bode, C. (2002). IgA against gut-derived endotoxins: Does it contribute to suppression of hepatic inflammation in alcohol-induced liver disease? Digestive Diseases and Sciences, 47(4), 760-766. https://doi.org/10.1023/A:1014783815433

Vancouver

Parlesak A, Schäfer C, Bode C. IgA against gut-derived endotoxins: Does it contribute to suppression of hepatic inflammation in alcohol-induced liver disease? Digestive Diseases and Sciences. 2002;47(4):760-766. https://doi.org/10.1023/A:1014783815433

Author

Parlesak, Alexandr ; Schäfer, Christian ; Bode, Christiane. / IgA against gut-derived endotoxins: Does it contribute to suppression of hepatic inflammation in alcohol-induced liver disease?. I: Digestive Diseases and Sciences. 2002 ; Bind 47, Nr. 4. s. 760-766.

Bibtex

@article{c1c54375fe3749ed978465dfeee83ea9,
title = "IgA against gut-derived endotoxins: Does it contribute to suppression of hepatic inflammation in alcohol-induced liver disease?",
abstract = "Endotoxins of intestinal origin are supposed to play an important role in the development of alcoholic hepatitis in man. To estimate the role of immunoglobulin response to gut-derived endotoxin in the development of alcohol-induced liver disease, serum levels of IgA and IgG against fecal endotoxin, endotoxin, and acute-phase proteins were measured in patients with different stages of alcoholic liver disease and in healthy controls. Antibodies of type IgA, but not IgG, against fecal endotoxins were significantly increased in patients with alcohol-induced liver disease. IgA antibodies against fecal endotoxin were found to be closely correlated with the plasma concentrations of alanine aminotransferase, γ-glutamyl transferase, and C-reactive protein in patients with alcoholic liver disease. In conclusion, as IgA located in body tissue was shown to suppress the inflammatory process, enhanced production of IgA against endotoxin of intestinal origin may contribute to inactivation of this compound, thereby reducing its damaging effect on the liver.",
author = "Alexandr Parlesak and Christian Sch{\"a}fer and Christiane Bode",
note = "(Ekstern)",
year = "2002",
doi = "10.1023/A:1014783815433",
language = "English",
volume = "47",
pages = "760--766",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - IgA against gut-derived endotoxins: Does it contribute to suppression of hepatic inflammation in alcohol-induced liver disease?

AU - Parlesak, Alexandr

AU - Schäfer, Christian

AU - Bode, Christiane

N1 - (Ekstern)

PY - 2002

Y1 - 2002

N2 - Endotoxins of intestinal origin are supposed to play an important role in the development of alcoholic hepatitis in man. To estimate the role of immunoglobulin response to gut-derived endotoxin in the development of alcohol-induced liver disease, serum levels of IgA and IgG against fecal endotoxin, endotoxin, and acute-phase proteins were measured in patients with different stages of alcoholic liver disease and in healthy controls. Antibodies of type IgA, but not IgG, against fecal endotoxins were significantly increased in patients with alcohol-induced liver disease. IgA antibodies against fecal endotoxin were found to be closely correlated with the plasma concentrations of alanine aminotransferase, γ-glutamyl transferase, and C-reactive protein in patients with alcoholic liver disease. In conclusion, as IgA located in body tissue was shown to suppress the inflammatory process, enhanced production of IgA against endotoxin of intestinal origin may contribute to inactivation of this compound, thereby reducing its damaging effect on the liver.

AB - Endotoxins of intestinal origin are supposed to play an important role in the development of alcoholic hepatitis in man. To estimate the role of immunoglobulin response to gut-derived endotoxin in the development of alcohol-induced liver disease, serum levels of IgA and IgG against fecal endotoxin, endotoxin, and acute-phase proteins were measured in patients with different stages of alcoholic liver disease and in healthy controls. Antibodies of type IgA, but not IgG, against fecal endotoxins were significantly increased in patients with alcohol-induced liver disease. IgA antibodies against fecal endotoxin were found to be closely correlated with the plasma concentrations of alanine aminotransferase, γ-glutamyl transferase, and C-reactive protein in patients with alcoholic liver disease. In conclusion, as IgA located in body tissue was shown to suppress the inflammatory process, enhanced production of IgA against endotoxin of intestinal origin may contribute to inactivation of this compound, thereby reducing its damaging effect on the liver.

U2 - 10.1023/A:1014783815433

DO - 10.1023/A:1014783815433

M3 - Journal article

VL - 47

SP - 760

EP - 766

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 4

ER -

ID: 317459658