Effect of acute negative and positive energy balance on basal very-low density lipoprotein triglyceride metabolism in women

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Effect of acute negative and positive energy balance on basal very-low density lipoprotein triglyceride metabolism in women. / Bellou, Elena; Maraki, Maria; Magkos, Faidon; Botonaki, Helena; Panagiotakos, Demosthenes B; Kavouras, Stavros A; Sidossis, Labros S.

I: P L o S One, Bind 8, Nr. 3, e60251, 2013.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Bellou, E, Maraki, M, Magkos, F, Botonaki, H, Panagiotakos, DB, Kavouras, SA & Sidossis, LS 2013, 'Effect of acute negative and positive energy balance on basal very-low density lipoprotein triglyceride metabolism in women', P L o S One, bind 8, nr. 3, e60251. https://doi.org/10.1371/journal.pone.0060251

APA

Bellou, E., Maraki, M., Magkos, F., Botonaki, H., Panagiotakos, D. B., Kavouras, S. A., & Sidossis, L. S. (2013). Effect of acute negative and positive energy balance on basal very-low density lipoprotein triglyceride metabolism in women. P L o S One, 8(3), [e60251]. https://doi.org/10.1371/journal.pone.0060251

Vancouver

Bellou E, Maraki M, Magkos F, Botonaki H, Panagiotakos DB, Kavouras SA o.a. Effect of acute negative and positive energy balance on basal very-low density lipoprotein triglyceride metabolism in women. P L o S One. 2013;8(3). e60251. https://doi.org/10.1371/journal.pone.0060251

Author

Bellou, Elena ; Maraki, Maria ; Magkos, Faidon ; Botonaki, Helena ; Panagiotakos, Demosthenes B ; Kavouras, Stavros A ; Sidossis, Labros S. / Effect of acute negative and positive energy balance on basal very-low density lipoprotein triglyceride metabolism in women. I: P L o S One. 2013 ; Bind 8, Nr. 3.

Bibtex

@article{c1139ae232b64ebcab62e2a6264becdc,
title = "Effect of acute negative and positive energy balance on basal very-low density lipoprotein triglyceride metabolism in women",
abstract = "Background: Acute reduction in dietary energy intake reduces very low-density lipoprotein triglyceride (VLDL-TG) concentration. Although chronic dietary energy surplus and obesity are associated with hypertriglyceridemia, the effect of acute overfeeding on VLDL-TG metabolism is not known.Objective: The aim of the present study was to investigate the effects of acute negative and positive energy balance on VLDL-TG metabolism in healthy women.Design: Ten healthy women (AGE: 22.0±2.9 years, BMI: 21.2±1.3 kg/m2) underwent a stable isotopically labeled tracer infusion study to determine basal VLDL-TG kinetics after performing, in random order, three experimental trials on the previous day: i) isocaloric feeding (control) ii) hypocaloric feeding with a dietary energy restriction of 2.89±0.42 MJ and iii) hypercaloric feeding with a dietary energy surplus of 2.91±0.32 MJ. The three diets had the same macronutrient composition.Results: Fasting plasma VLDL-TG concentrations decreased by ∼26% after hypocaloric feeding relative to the control trial (P = 0.037), owing to decreased hepatic VLDL-TG secretion rate (by 21%, P = 0.023) and increased VLDL-TG plasma clearance rate (by ∼12%, P = 0.016). Hypercaloric feeding increased plasma glucose concentration (P = 0.042) but had no effect on VLDL-TG concentration and kinetics compared to the control trial.Conclusion: Acute dietary energy deficit (∼3MJ) leads to hypotriglyceridemia via a combination of decreased hepatic VLDL-TG secretion and increased VLDL-TG clearance. On the other hand, acute dietary energy surplus (∼3MJ) does not affect basal VLDL-TG metabolism but disrupts glucose homeostasis in healthy women.",
keywords = "Adult, Energy Metabolism/physiology, Female, Humans, Hypertriglyceridemia/blood, Lipoproteins, VLDL/blood, Triglycerides/blood, Young Adult",
author = "Elena Bellou and Maria Maraki and Faidon Magkos and Helena Botonaki and Panagiotakos, {Demosthenes B} and Kavouras, {Stavros A} and Sidossis, {Labros S}",
note = "(Ekstern)",
year = "2013",
doi = "10.1371/journal.pone.0060251",
language = "English",
volume = "8",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

}

RIS

TY - JOUR

T1 - Effect of acute negative and positive energy balance on basal very-low density lipoprotein triglyceride metabolism in women

AU - Bellou, Elena

AU - Maraki, Maria

AU - Magkos, Faidon

AU - Botonaki, Helena

AU - Panagiotakos, Demosthenes B

AU - Kavouras, Stavros A

AU - Sidossis, Labros S

N1 - (Ekstern)

PY - 2013

Y1 - 2013

N2 - Background: Acute reduction in dietary energy intake reduces very low-density lipoprotein triglyceride (VLDL-TG) concentration. Although chronic dietary energy surplus and obesity are associated with hypertriglyceridemia, the effect of acute overfeeding on VLDL-TG metabolism is not known.Objective: The aim of the present study was to investigate the effects of acute negative and positive energy balance on VLDL-TG metabolism in healthy women.Design: Ten healthy women (AGE: 22.0±2.9 years, BMI: 21.2±1.3 kg/m2) underwent a stable isotopically labeled tracer infusion study to determine basal VLDL-TG kinetics after performing, in random order, three experimental trials on the previous day: i) isocaloric feeding (control) ii) hypocaloric feeding with a dietary energy restriction of 2.89±0.42 MJ and iii) hypercaloric feeding with a dietary energy surplus of 2.91±0.32 MJ. The three diets had the same macronutrient composition.Results: Fasting plasma VLDL-TG concentrations decreased by ∼26% after hypocaloric feeding relative to the control trial (P = 0.037), owing to decreased hepatic VLDL-TG secretion rate (by 21%, P = 0.023) and increased VLDL-TG plasma clearance rate (by ∼12%, P = 0.016). Hypercaloric feeding increased plasma glucose concentration (P = 0.042) but had no effect on VLDL-TG concentration and kinetics compared to the control trial.Conclusion: Acute dietary energy deficit (∼3MJ) leads to hypotriglyceridemia via a combination of decreased hepatic VLDL-TG secretion and increased VLDL-TG clearance. On the other hand, acute dietary energy surplus (∼3MJ) does not affect basal VLDL-TG metabolism but disrupts glucose homeostasis in healthy women.

AB - Background: Acute reduction in dietary energy intake reduces very low-density lipoprotein triglyceride (VLDL-TG) concentration. Although chronic dietary energy surplus and obesity are associated with hypertriglyceridemia, the effect of acute overfeeding on VLDL-TG metabolism is not known.Objective: The aim of the present study was to investigate the effects of acute negative and positive energy balance on VLDL-TG metabolism in healthy women.Design: Ten healthy women (AGE: 22.0±2.9 years, BMI: 21.2±1.3 kg/m2) underwent a stable isotopically labeled tracer infusion study to determine basal VLDL-TG kinetics after performing, in random order, three experimental trials on the previous day: i) isocaloric feeding (control) ii) hypocaloric feeding with a dietary energy restriction of 2.89±0.42 MJ and iii) hypercaloric feeding with a dietary energy surplus of 2.91±0.32 MJ. The three diets had the same macronutrient composition.Results: Fasting plasma VLDL-TG concentrations decreased by ∼26% after hypocaloric feeding relative to the control trial (P = 0.037), owing to decreased hepatic VLDL-TG secretion rate (by 21%, P = 0.023) and increased VLDL-TG plasma clearance rate (by ∼12%, P = 0.016). Hypercaloric feeding increased plasma glucose concentration (P = 0.042) but had no effect on VLDL-TG concentration and kinetics compared to the control trial.Conclusion: Acute dietary energy deficit (∼3MJ) leads to hypotriglyceridemia via a combination of decreased hepatic VLDL-TG secretion and increased VLDL-TG clearance. On the other hand, acute dietary energy surplus (∼3MJ) does not affect basal VLDL-TG metabolism but disrupts glucose homeostasis in healthy women.

KW - Adult

KW - Energy Metabolism/physiology

KW - Female

KW - Humans

KW - Hypertriglyceridemia/blood

KW - Lipoproteins, VLDL/blood

KW - Triglycerides/blood

KW - Young Adult

U2 - 10.1371/journal.pone.0060251

DO - 10.1371/journal.pone.0060251

M3 - Journal article

C2 - 23533676

VL - 8

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 3

M1 - e60251

ER -

ID: 289969963