Unresolved questions in the regulation of skeletal muscle insulin action by reactive oxygen species
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Unresolved questions in the regulation of skeletal muscle insulin action by reactive oxygen species. / Gallero, Samantha; Persson, Kaspar W.; Henríquez-Olguín, Carlos.
I: FEBS Letters, 2024.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Unresolved questions in the regulation of skeletal muscle insulin action by reactive oxygen species
AU - Gallero, Samantha
AU - Persson, Kaspar W.
AU - Henríquez-Olguín, Carlos
N1 - Publisher Copyright: © 2024 The Author(s). FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
PY - 2024
Y1 - 2024
N2 - Reactive oxygen species (ROS) are well-established signaling molecules implicated in a wide range of cellular processes, including both oxidative stress and intracellular redox signaling. In the context of insulin action within its target tissues, ROS have been reported to exert both positive and negative regulatory effects. However, the precise molecular mechanisms underlying this duality remain unclear. This Review examines the complex role of ROS in insulin action, with a particular focus on skeletal muscle. We aim to address three critical aspects: (a) the proposed intracellular pro-oxidative redox shift elicited by insulin, (b) the evidence supporting that redox-sensitive cysteine modifications impact insulin signaling and action, and (c) cellular mechanisms underlying how ROS can paradoxically act as both enhancers and inhibitors of insulin action. This Review underscores the urgent need for more systematic research to identify specific reactive species, redox targets, and the physiological significance of redox signaling in maintaining insulin action and metabolic health, with a particular emphasis on human skeletal muscle.
AB - Reactive oxygen species (ROS) are well-established signaling molecules implicated in a wide range of cellular processes, including both oxidative stress and intracellular redox signaling. In the context of insulin action within its target tissues, ROS have been reported to exert both positive and negative regulatory effects. However, the precise molecular mechanisms underlying this duality remain unclear. This Review examines the complex role of ROS in insulin action, with a particular focus on skeletal muscle. We aim to address three critical aspects: (a) the proposed intracellular pro-oxidative redox shift elicited by insulin, (b) the evidence supporting that redox-sensitive cysteine modifications impact insulin signaling and action, and (c) cellular mechanisms underlying how ROS can paradoxically act as both enhancers and inhibitors of insulin action. This Review underscores the urgent need for more systematic research to identify specific reactive species, redox targets, and the physiological significance of redox signaling in maintaining insulin action and metabolic health, with a particular emphasis on human skeletal muscle.
KW - hydrogen peroxide
KW - insulin action
KW - insulin signaling
KW - metabolism
KW - reactive oxygen species
KW - redox signaling
KW - skeletal muscle
U2 - 10.1002/1873-3468.14937
DO - 10.1002/1873-3468.14937
M3 - Review
C2 - 38803005
AN - SCOPUS:85194565971
JO - F E B S Letters
JF - F E B S Letters
SN - 0014-5793
ER -
ID: 395072961