TY - JOUR

T1 - Factors regulating fat oxidation in human skeletal muscle

AU - Kiens, Bente

AU - Alsted, Thomas Junker

AU - Jeppesen, Jacob

N1 - CURIS 2011 5200 119

PY - 2011

Y1 - 2011

N2 - In modern societies, oversupply of calories leads to obesity and chronic metabolic stress, which may lead to development of disease. Oversupply of calories is often associated with elevated plasma lipid concentrations and accumulation of lipids in skeletal muscle leading to decreased insulin sensitivity. Consequently, enhanced fat oxidation might be beneficial in counteracting lipid accumulation. Exercise is the most effective way to increase fat oxidation, because it increases metabolic rate. Lipid metabolism can also be altered by dietary manipulations. Thus, a fat rich diet leads to increased potential for fat oxidation by increasing the content of several of the proteins in the fat oxidative pathway. The regulation of both exercise and diet induced lipid oxidation will be discussed in this review.

AB - In modern societies, oversupply of calories leads to obesity and chronic metabolic stress, which may lead to development of disease. Oversupply of calories is often associated with elevated plasma lipid concentrations and accumulation of lipids in skeletal muscle leading to decreased insulin sensitivity. Consequently, enhanced fat oxidation might be beneficial in counteracting lipid accumulation. Exercise is the most effective way to increase fat oxidation, because it increases metabolic rate. Lipid metabolism can also be altered by dietary manipulations. Thus, a fat rich diet leads to increased potential for fat oxidation by increasing the content of several of the proteins in the fat oxidative pathway. The regulation of both exercise and diet induced lipid oxidation will be discussed in this review.

U2 - 10.1111/j.1467-789X.2011.00898.x

DO - 10.1111/j.1467-789X.2011.00898.x

M3 - Review

C2 - 21951332

VL - 12

SP - 852

EP - 858

JO - Obesity Reviews

JF - Obesity Reviews

SN - 1467-7881

IS - 10

ER -