Losing the dogmatic view of cerebral autoregulation

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Losing the dogmatic view of cerebral autoregulation. / Brassard, Patrice; Labrecque, Lawrence; Smirl, Jonathan D; Tymko, Michael M; Caldwell, Hannah Grace; Hoiland, Ryan L; Lucas, Samuel J E; Denault, André Y; Couture, Etienne J; Ainslie, Philip N.

I: Physiological Reports, Bind 9, Nr. 15, e14982, 2021.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Brassard, P, Labrecque, L, Smirl, JD, Tymko, MM, Caldwell, HG, Hoiland, RL, Lucas, SJE, Denault, AY, Couture, EJ & Ainslie, PN 2021, 'Losing the dogmatic view of cerebral autoregulation', Physiological Reports, bind 9, nr. 15, e14982. https://doi.org/10.14814/phy2.14982

APA

Brassard, P., Labrecque, L., Smirl, J. D., Tymko, M. M., Caldwell, H. G., Hoiland, R. L., Lucas, S. J. E., Denault, A. Y., Couture, E. J., & Ainslie, P. N. (2021). Losing the dogmatic view of cerebral autoregulation. Physiological Reports, 9(15), [e14982]. https://doi.org/10.14814/phy2.14982

Vancouver

Brassard P, Labrecque L, Smirl JD, Tymko MM, Caldwell HG, Hoiland RL o.a. Losing the dogmatic view of cerebral autoregulation. Physiological Reports. 2021;9(15). e14982. https://doi.org/10.14814/phy2.14982

Author

Brassard, Patrice ; Labrecque, Lawrence ; Smirl, Jonathan D ; Tymko, Michael M ; Caldwell, Hannah Grace ; Hoiland, Ryan L ; Lucas, Samuel J E ; Denault, André Y ; Couture, Etienne J ; Ainslie, Philip N. / Losing the dogmatic view of cerebral autoregulation. I: Physiological Reports. 2021 ; Bind 9, Nr. 15.

Bibtex

@article{5fbad67840534390b23bffa21d21b129,
title = "Losing the dogmatic view of cerebral autoregulation",
abstract = "In 1959, Niels Lassen illustrated the cerebral autoregulation curve in the classic review article entitled Cerebral Blood Flow and Oxygen Consumption in Man. This concept suggested a relatively broad mean arterial pressure range (~60–150 mmHg) wherein cerebral blood flow remains constant. However, the assumption that this wide cerebral autoregulation plateau could be applied on a within-individual basis is incorrect and greatly variable between individuals. Indeed, each data point on the autoregulatory curve originated from independent samples of participants and patients and represented interindividual relationships between cerebral blood flow and mean arterial pressure. Nonetheless, this influential concept remains commonly cited and illustrated in various high-impact publications and medical textbooks, and is frequently taught in medical and science education without appropriate nuances and caveats. Herein, we provide the rationale and additional experimental data supporting the notion we need to lose this dogmatic view of cerebral autoregulation.",
keywords = "Arterial blood pressure, Autoregulatory curve, Cerebral autoregulation, Cerebral blood flow, Lassen",
author = "Patrice Brassard and Lawrence Labrecque and Smirl, {Jonathan D} and Tymko, {Michael M} and Caldwell, {Hannah Grace} and Hoiland, {Ryan L} and Lucas, {Samuel J E} and Denault, {Andr{\'e} Y} and Couture, {Etienne J} and Ainslie, {Philip N}",
note = "Publisher Copyright: {\textcopyright} 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society",
year = "2021",
doi = "10.14814/phy2.14982",
language = "English",
volume = "9",
journal = "Physiological Reports",
issn = "2051-817X",
publisher = "Wiley Periodicals, Inc.",
number = "15",

}

RIS

TY - JOUR

T1 - Losing the dogmatic view of cerebral autoregulation

AU - Brassard, Patrice

AU - Labrecque, Lawrence

AU - Smirl, Jonathan D

AU - Tymko, Michael M

AU - Caldwell, Hannah Grace

AU - Hoiland, Ryan L

AU - Lucas, Samuel J E

AU - Denault, André Y

AU - Couture, Etienne J

AU - Ainslie, Philip N

N1 - Publisher Copyright: © 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society

PY - 2021

Y1 - 2021

N2 - In 1959, Niels Lassen illustrated the cerebral autoregulation curve in the classic review article entitled Cerebral Blood Flow and Oxygen Consumption in Man. This concept suggested a relatively broad mean arterial pressure range (~60–150 mmHg) wherein cerebral blood flow remains constant. However, the assumption that this wide cerebral autoregulation plateau could be applied on a within-individual basis is incorrect and greatly variable between individuals. Indeed, each data point on the autoregulatory curve originated from independent samples of participants and patients and represented interindividual relationships between cerebral blood flow and mean arterial pressure. Nonetheless, this influential concept remains commonly cited and illustrated in various high-impact publications and medical textbooks, and is frequently taught in medical and science education without appropriate nuances and caveats. Herein, we provide the rationale and additional experimental data supporting the notion we need to lose this dogmatic view of cerebral autoregulation.

AB - In 1959, Niels Lassen illustrated the cerebral autoregulation curve in the classic review article entitled Cerebral Blood Flow and Oxygen Consumption in Man. This concept suggested a relatively broad mean arterial pressure range (~60–150 mmHg) wherein cerebral blood flow remains constant. However, the assumption that this wide cerebral autoregulation plateau could be applied on a within-individual basis is incorrect and greatly variable between individuals. Indeed, each data point on the autoregulatory curve originated from independent samples of participants and patients and represented interindividual relationships between cerebral blood flow and mean arterial pressure. Nonetheless, this influential concept remains commonly cited and illustrated in various high-impact publications and medical textbooks, and is frequently taught in medical and science education without appropriate nuances and caveats. Herein, we provide the rationale and additional experimental data supporting the notion we need to lose this dogmatic view of cerebral autoregulation.

KW - Arterial blood pressure

KW - Autoregulatory curve

KW - Cerebral autoregulation

KW - Cerebral blood flow

KW - Lassen

UR - http://www.scopus.com/inward/record.url?scp=85112358382&partnerID=8YFLogxK

U2 - 10.14814/phy2.14982

DO - 10.14814/phy2.14982

M3 - Review

C2 - 34323023

AN - SCOPUS:85112358382

VL - 9

JO - Physiological Reports

JF - Physiological Reports

SN - 2051-817X

IS - 15

M1 - e14982

ER -

ID: 306296029