Hourly staircase sprinting exercise “snacks” improve femoral artery shear patterns but not flow-mediated dilation or cerebrovascular regulation: A pilot study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Healthy males (n = 10; age: 24 ± 4 years; bodymass index: 24 6 2 kg·m-2) completed 2 randomized conditions separated by ≥48 h involving 6-8.5 h of sitting with (“stair snacks”) and without (sedentary) hourly staircase sprint interval exercise (~14-20 s each). Resting blood flow and shear rates were measured in the femoral artery, internal carotid artery, and vertebral artery (Duplex ultrasound). Flow-mediated dilation (FMD) was quantified as an index of peripheral endothelial function in the femoral artery. Neurovascular coupling (NVC; regional blood flow response to local increases in cerebral metabolism) was assessed in the posterior cerebral artery (transcranial Doppler ultrasound). Femoral artery hemodynamics were higher following the active trial with no change in the sedentary trial, including blood flow (+32 6 23% vs. -10 ± 28%; P = 0.015 and P = 0.253, respectively), vascular conductance (+32 ± 27% vs. _15 6 26%; P = 0.012 and P = 0.098, respectively), and mean shear rate (+17 6 8% vs. -8 ± 28%; P = 0.004 and P = 0.310, respectively). The change in FMD was not different within or between conditions (P = 0.184). Global cerebral blood flow (CBF), conductance, shear patterns, and NVC were not different within or between conditions (all P > 0.05). Overall, exercise “stair snacks” improve femoral artery blood flow and shear patterns but not peripheral (e.g., FMD) or cerebral (e.g., CBF and NVC) vascular function following prolonged sitting.
The study was registered at Clinical- Trials.gov (NCT03374436).
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Applied Physiology, Nutrition and Metabolism |
| Vol/bind | 46 |
| Udgave nummer | 5 |
| Sider (fra-til) | 521-529 |
| Antal sider | 9 |
| ISSN | 1715-5312 |
| DOI | |
| Status | Udgivet - 2021 |
| Eksternt udgivet | Ja |
Bibliografisk note
(Ekstern)
Funding Information:
Dr. Little reports grants from Canadian Institutes for Health Research, Michael Smith Foundation for Health Research, Mitacs Accelerate, and the Natural Sciences and Engineering Research Council during the conduct of the study; Dr. Little holds shares and provides scientific advice to Metabolic Insights Inc. and is Chief Scientific Officer for the Institute for Personalized Therapeutic Nutrition, which are both outside the submitted work.
Funding Information:
We appreciate the time and effort spent by our volunteer participants in the present study. J.P.L. is supported by a Canadian Institutes of Health Research (CIHR) New Investigator Salary Award (MSH-141980 + FRN-152999) and a Michael Smith Foundation for Health Research (MSFHR) Scholar Award (Scholar Award no. 16890). P.N.A. is supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) and a Canada Research Chair (F11-02423). H.R. received funding from Mitacs Accelerate. Author contributions: This study was performed at The University of British Columbia Okanagan in Kelowna, British Columbia, Canada. H.G.C., G.B.C., H.R., P.N.A., and J.P.L. conceived and designed the research. H.G.C., G.B.C., and H.R. acquired the data. H.G.C. and G.B.C. analyzed the data. H.G.C., G.B.C., P.N.A., and J.P.L. interpreted the data. H.G.C. drafted the manuscript. All authors revised the manuscript and provided intellectual feedback and agree to be accountable for all aspects of the work.
Publisher Copyright:
© 2021, Canadian Science Publishing. All rights reserved.
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