Differential vasomotor responses to isocapnic hyperoxia: cerebral versus peripheral circulation
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Differential vasomotor responses to isocapnic hyperoxia: cerebral versus peripheral circulation. / Mattos, João D; Campos, Monique O; Rocha, Marcos Paulo; Mansur, Daniel E; Rocha, Helena N M; Garcia, Vinicius P; Rocha, Natalia G; Alvares, Thiago S; Secher, Niels H.; Nóbrega, Antonio C L; Fernandes, Igor A.
I: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Bind 318, Nr. 1, 2020, s. R182-R187.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Differential vasomotor responses to isocapnic hyperoxia: cerebral versus peripheral circulation
AU - Mattos, João D
AU - Campos, Monique O
AU - Rocha, Marcos Paulo
AU - Mansur, Daniel E
AU - Rocha, Helena N M
AU - Garcia, Vinicius P
AU - Rocha, Natalia G
AU - Alvares, Thiago S
AU - Secher, Niels H.
AU - Nóbrega, Antonio C L
AU - Fernandes, Igor A
N1 - (Ekstern)
PY - 2020
Y1 - 2020
N2 - Isocapnic hyperoxia (IH) evokes cerebral and peripheral hypoperfusion via both disturbance of redox homeostasis and reduction in nitric oxide (NO) bioavailability. However, it is not clear whether the magnitude of the vasomotor responses depends on the vessel network exposed to IH. To test the hypothesis that the magnitude of IH-induced reduction in peripheral blood flow (BF) may differ from the hypoperfusion response observed in the cerebral vascular network under oxygen-enriched conditions, nine healthy men (25 ± 3 yr, mean ± SD) underwent 10 min of IH during either saline or vitamin C (3 g) infusion, separately. Femoral artery (FA), internal carotid artery (ICA), and vertebral artery (VA) BF (Doppler ultrasound), as well as arterial oxidant (8-isoprostane), antioxidant [ascorbic acid (AA)], and NO bioavailability (nitrite) markers were simultaneously measured. IH increased 8-isoprostane levels and reduced nitrite levels; these responses were followed by a reduction in both FA BF and ICA BF, whereas VA BF did not change. Absolute and relative reductions in FA BF were greater than IH-induced changes in ICA and VA perfusion. Vitamin C infusion increased arterial AA levels and abolished the IH-induced increase in 8-isoprostane levels and reduction in nitrite levels. Whereas ICA and VA BF did not change during the vitamin C-IH trial, FA perfusion increased and reached similar levels to those observed during normoxia with saline infusion. Therefore, the magnitude of IH-induced reduction in femoral blood flow is greater than that observed in the vessel network of the brain, which might involve the determinant contribution that NO has in the regulation of peripheral vascular perfusion.
AB - Isocapnic hyperoxia (IH) evokes cerebral and peripheral hypoperfusion via both disturbance of redox homeostasis and reduction in nitric oxide (NO) bioavailability. However, it is not clear whether the magnitude of the vasomotor responses depends on the vessel network exposed to IH. To test the hypothesis that the magnitude of IH-induced reduction in peripheral blood flow (BF) may differ from the hypoperfusion response observed in the cerebral vascular network under oxygen-enriched conditions, nine healthy men (25 ± 3 yr, mean ± SD) underwent 10 min of IH during either saline or vitamin C (3 g) infusion, separately. Femoral artery (FA), internal carotid artery (ICA), and vertebral artery (VA) BF (Doppler ultrasound), as well as arterial oxidant (8-isoprostane), antioxidant [ascorbic acid (AA)], and NO bioavailability (nitrite) markers were simultaneously measured. IH increased 8-isoprostane levels and reduced nitrite levels; these responses were followed by a reduction in both FA BF and ICA BF, whereas VA BF did not change. Absolute and relative reductions in FA BF were greater than IH-induced changes in ICA and VA perfusion. Vitamin C infusion increased arterial AA levels and abolished the IH-induced increase in 8-isoprostane levels and reduction in nitrite levels. Whereas ICA and VA BF did not change during the vitamin C-IH trial, FA perfusion increased and reached similar levels to those observed during normoxia with saline infusion. Therefore, the magnitude of IH-induced reduction in femoral blood flow is greater than that observed in the vessel network of the brain, which might involve the determinant contribution that NO has in the regulation of peripheral vascular perfusion.
KW - Brain blood flow
KW - Hyperoxia
KW - Peripheral blood flow
U2 - 10.1152/ajpregu.00248.2019
DO - 10.1152/ajpregu.00248.2019
M3 - Journal article
C2 - 31644318
VL - 318
SP - R182-R187
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6119
IS - 1
ER -
ID: 257928281