DITO

We hope that the findings from this research will improve our understanding of age-related changes in metabolism and contribute to the development of future nutritional strategies that support healthy ageing.

Diet-induced thermogenesis (DIT) is the increase in energy expenditure above basal metabolic rate (BMR) that occurs after food intake and typically accounts for approximately 10–15% of total daily energy expenditure.

While previous studies suggest that DIT may decline with age, findings remain inconsistent due to differences in study design, meal characteristics, participant populations, and measurement protocols.

Furthermore, it remains unknown whether ageing influences the thermogenic response to different macronutrients or whether food form (liquid versus solid meals) modifies this response.

To answer these questions, DITO was designed as a randomized crossover trial investigating the effects of age, macronutrient composition, and food form on diet-induced thermogenesis, with the aim of improving our understanding of age-related changes in metabolism and contribute to the development of future nutritional strategies that support healthy ageing.