Bioimpedance index for measurement of total body water in severely malnourished children: Assessing the effect of nutritional oedema
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Bioimpedance index for measurement of total body water in severely malnourished children : Assessing the effect of nutritional oedema. / Girma, Tsinuel; Kæstel, Pernille; Workeneh, Netsanet; Mølgaard, Christian; Eaton, Simon; Andersen, Gregers S; Michaelsen, Kim F.; Friis, Henrik; Wells, Jonathan C K.
I: Clinical Nutrition, Bind 35, Nr. 3, 2016, s. 713-717.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Bioimpedance index for measurement of total body water in severely malnourished children
T2 - Assessing the effect of nutritional oedema
AU - Girma, Tsinuel
AU - Kæstel, Pernille
AU - Workeneh, Netsanet
AU - Mølgaard, Christian
AU - Eaton, Simon
AU - Andersen, Gregers S
AU - Michaelsen, Kim F.
AU - Friis, Henrik
AU - Wells, Jonathan C K
N1 - CURIS 2016 NEXS 108
PY - 2016
Y1 - 2016
N2 - BACKGROUND & OBJECTIVES: Restoration of body composition indicates successful management of severe acute malnutrition (SAM). Bioimpedance (BI) index (height(2)/resistance) is used to predict total body water (TBW) but its performance in SAM, especially with oedema, requires further investigation.SUBJECTS/METHODS: Children with SAM (mid-arm circumference <11.0 cm or weight-for-height <70% of median of NCHS reference and/or nutritional oedema) admitted to Jimma University Hospital were included. Tetrapolar-whole-body impedance (Z), resistance (R) and reactance (Xc) were measured at 50 and 200 kHzs. Pre- and post-deuterium dose saliva samples were analysed using isotope-ratio mass spectrometry. TBW was regressed on H(2)/Z. Xc and R were height (H)-indexed, and Xc/H plotted against R/H.RESULTS: Thirty five children (16 non-oedematous and 19 oedematous) with median (interquartile range) age of 42 (26-54) months were studied. Height-for-age z-score (mean ± SD) was low in both non-oedematous (-3.9 ± 2.8) and oedematous (-3.6 ± 1.7) children. Oedematous children had lower BI parameters than non-oedematous (p < 0.001) and hence higher H(2)/Z for a given amount of TBW. At both 50 and 200 kHz, association between H(2)/Z and TBW was stronger in non-oedematous children than oedematous (60% higher coefficient of determination and 20% lower standard error of estimate). Intercepts and regression estimates at 50 and 200 kHz were similar, in both oedematous and non-oedematous children.CONCLUSIONS: In children with oedematous SAM, BI index was weak in predicting TBW. Moreover, predicted TBWs at 200 kHz and 50 kHz did not differ and hence BI measurement at 50 kHz is still practical for TBW estimation.
AB - BACKGROUND & OBJECTIVES: Restoration of body composition indicates successful management of severe acute malnutrition (SAM). Bioimpedance (BI) index (height(2)/resistance) is used to predict total body water (TBW) but its performance in SAM, especially with oedema, requires further investigation.SUBJECTS/METHODS: Children with SAM (mid-arm circumference <11.0 cm or weight-for-height <70% of median of NCHS reference and/or nutritional oedema) admitted to Jimma University Hospital were included. Tetrapolar-whole-body impedance (Z), resistance (R) and reactance (Xc) were measured at 50 and 200 kHzs. Pre- and post-deuterium dose saliva samples were analysed using isotope-ratio mass spectrometry. TBW was regressed on H(2)/Z. Xc and R were height (H)-indexed, and Xc/H plotted against R/H.RESULTS: Thirty five children (16 non-oedematous and 19 oedematous) with median (interquartile range) age of 42 (26-54) months were studied. Height-for-age z-score (mean ± SD) was low in both non-oedematous (-3.9 ± 2.8) and oedematous (-3.6 ± 1.7) children. Oedematous children had lower BI parameters than non-oedematous (p < 0.001) and hence higher H(2)/Z for a given amount of TBW. At both 50 and 200 kHz, association between H(2)/Z and TBW was stronger in non-oedematous children than oedematous (60% higher coefficient of determination and 20% lower standard error of estimate). Intercepts and regression estimates at 50 and 200 kHz were similar, in both oedematous and non-oedematous children.CONCLUSIONS: In children with oedematous SAM, BI index was weak in predicting TBW. Moreover, predicted TBWs at 200 kHz and 50 kHz did not differ and hence BI measurement at 50 kHz is still practical for TBW estimation.
U2 - 10.1016/j.clnu.2015.05.002
DO - 10.1016/j.clnu.2015.05.002
M3 - Journal article
C2 - 26189699
VL - 35
SP - 713
EP - 717
JO - Clinical Nutrition
JF - Clinical Nutrition
SN - 0261-5614
IS - 3
ER -
ID: 141994935