Dietary regulation of hepatic triacylglycerol content: the role of eucaloric carbohydrate restriction with fat or protein replacement
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Dietary regulation of hepatic triacylglycerol content : the role of eucaloric carbohydrate restriction with fat or protein replacement. / Lundsgaard, Annemarie; Bojsen-Møller, Kirstine Nyvold; Kiens, Bente.
In: Advances in Nutrition, Vol. 14, No. 6, 2023, p. 1359-1373.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Dietary regulation of hepatic triacylglycerol content
T2 - the role of eucaloric carbohydrate restriction with fat or protein replacement
AU - Lundsgaard, Annemarie
AU - Bojsen-Møller, Kirstine Nyvold
AU - Kiens, Bente
N1 - Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Accumulation of hepatic triacylglycerol (TG) is highly associated with impaired whole-body insulin-glucose homeostasis and dyslipidemia. The summarized findings from human intervention studies investigating the effect of reduced dietary carbohydrate and increased fat intake (and in studies also increased protein) while maintaining energy intake at eucaloric requirements reveal a beneficial effect of carbohydrate reduction on hepatic TG content in obese individuals with steatosis and indices of insulin resistance. Evidence suggests that the reduction of hepatic TG content following reduced intake of carbohydrate and increased fat/protein intake in humans results from regulation of fatty acid (FA) metabolism within the liver, with an increase in hepatic FA oxidation and ketogenesis, together with a concomitant downregulation of FA synthesis from de novo lipogenesis. The adaptations in hepatic metabolism may result from reduced intrahepatic monosaccharide and insulin availability, reduced glycolysis and increased FA availability when carbohydrate intake is reduced.
AB - Accumulation of hepatic triacylglycerol (TG) is highly associated with impaired whole-body insulin-glucose homeostasis and dyslipidemia. The summarized findings from human intervention studies investigating the effect of reduced dietary carbohydrate and increased fat intake (and in studies also increased protein) while maintaining energy intake at eucaloric requirements reveal a beneficial effect of carbohydrate reduction on hepatic TG content in obese individuals with steatosis and indices of insulin resistance. Evidence suggests that the reduction of hepatic TG content following reduced intake of carbohydrate and increased fat/protein intake in humans results from regulation of fatty acid (FA) metabolism within the liver, with an increase in hepatic FA oxidation and ketogenesis, together with a concomitant downregulation of FA synthesis from de novo lipogenesis. The adaptations in hepatic metabolism may result from reduced intrahepatic monosaccharide and insulin availability, reduced glycolysis and increased FA availability when carbohydrate intake is reduced.
KW - Faculty of Science
KW - NAFLD
KW - MAFLD
KW - Fatty liver
KW - Diet
KW - Steatosis
KW - Carbohydrate
KW - Fatty acids
KW - Fatty acid oxidation
U2 - 10.1016/j.advnut.2023.08.005
DO - 10.1016/j.advnut.2023.08.005
M3 - Review
C2 - 37591342
VL - 14
SP - 1359
EP - 1373
JO - Advances in Nutrition
JF - Advances in Nutrition
SN - 2161-8313
IS - 6
ER -
ID: 362792178