Early life DNA vaccination with the H gene of Canine distemper virus induces robust protection against distemper
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Early life DNA vaccination with the H gene of Canine distemper virus induces robust protection against distemper. / Jensen, Trine Hammer; Nielsen, Line; Aasted, Bent; Blixenkrone-Møller, Merete.
In: Vaccine, Vol. 27, No. 38, 2009, p. 5178–5183.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Early life DNA vaccination with the H gene of Canine distemper virus induces robust protection against distemper
AU - Jensen, Trine Hammer
AU - Nielsen, Line
AU - Aasted, Bent
AU - Blixenkrone-Møller, Merete
PY - 2009
Y1 - 2009
N2 - Young mink kits (n = 8)were vaccinated withDNA plasmids encoding the viral haemagglutinin protein (H) of a vaccine strain of Canine distemper virus (CDV). Virus neutralising (VN) antibodieswere induced after 2 immunisations and after the third immunisation all kits had high VN antibody titres. The VN antibody titres remained high for more than 4 months and the mink were protected against viraemia, lymphopenia, clinical disease and changes in the percentage of IFN- producing peripheral blood leucocytes after challenge inoculation with a recent wild type strain of CDV. Essentially, these results demonstrate that early life DNA vaccination with the H gene of a CDV vaccine strain induced robust protective immunity against a recent wild type CDV.
AB - Young mink kits (n = 8)were vaccinated withDNA plasmids encoding the viral haemagglutinin protein (H) of a vaccine strain of Canine distemper virus (CDV). Virus neutralising (VN) antibodieswere induced after 2 immunisations and after the third immunisation all kits had high VN antibody titres. The VN antibody titres remained high for more than 4 months and the mink were protected against viraemia, lymphopenia, clinical disease and changes in the percentage of IFN- producing peripheral blood leucocytes after challenge inoculation with a recent wild type strain of CDV. Essentially, these results demonstrate that early life DNA vaccination with the H gene of a CDV vaccine strain induced robust protective immunity against a recent wild type CDV.
KW - Former Faculty of Life Sciences
U2 - 10.1016/j.vaccine.2009.06.077
DO - 10.1016/j.vaccine.2009.06.077
M3 - Journal article
C2 - 19596418
VL - 27
SP - 5178
EP - 5183
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 38
ER -
ID: 13458253