The effect of special diets on weight and nutritional intake in hematological cancer patients: A randomized study

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Major weight loss and taste changes are well documented in patients with hematological cancer during chemotherapy. We have previously documented, that such patients have preferences for much umami, a little sweet, sour and salt, and no bitter. We wanted to convert these results into real diets. Patients participated in two sensory pilot studies (n = 10), where dishes were tested for preferences before and after chemotherapy. From these results, four dishes were selected and tested on 32 patients in 30 days in a cross-over design. The diets resulted in a beneficial and statistically significant difference in weight development (p = 0.0008), with 1.2 ± 1.9 kg (+2%) in the intervention period and -2.8 ± 5.2 kg (-4%) in the control period. This difference persisted after sensitivity analysis (±10%) P = 0.005. However, the nutritional intake was still low in both periods, and the treatment with cytarabine turned out to be a major confounder as dosage was significantly higher in the control period.

OriginalsprogEngelsk
TidsskriftNutrition and Cancer
Vol/bind70
Udgave nummer6
Sider (fra-til)874-878
Antal sider5
ISSN0163-5581
DOI
StatusUdgivet - 2018

Bibliografisk note

CURIS 2018 NEXS 279

ID: 201043599