GLP-1 increases microvascular recruitment but not glucose uptake in human and rat skeletal muscle

Publikation: Bidrag til tidsskriftTidsskriftartikel

The insulinotropic gut hormone, glucagon-like-peptide-1 (GLP-1) has been proposed to have effects on vascular function and glucose disposal. However, whether GLP-1 is able to increase microvascular recruitment (MVR) in humans has not been investigated. GLP-1 was infused in the femoral artery in overnight fasted healthy young men. Microvascular recruitment was measured with real time contrast-enhanced ultrasound and leg glucose uptake by the leg balance technique with and without inhibition of the insulinotropic response of GLP-1 by co-infusion of octreotide. As a positive control, MVR and leg glucose uptake were measured during a hyperinsulinemic euglycemic clamp. Infusion of GLP-1 caused a rapid increase (P
OriginalsprogEngelsk
TidsskriftAmerican Journal of Physiology: Endocrinology and Metabolism
Vol/bind306
Udgave nummer4
Sider (fra-til)E355-E362
Antal sider8
ISSN0193-1849
DOI
StatusUdgivet - 2014

Bibliografisk note

CURIS 2014 NEXS 054

ID: 92062721