Jørgen Wojtaszewski

Jørgen Wojtaszewski


Medlem af:

    ResearcherID: P-6583-2014

    Scopus Author ID: 12774513500

    Primære forskningsområder

    Our research focus on the mechanism(s) by which physical activity promotes metabolic health. Our studies have focused on the role of the energy sensor AMP activated protein kinase in promoting adaptations to exercise training and to a single bout of exercise. Of particular interest for now more than 20 years have been the interaction at the intracellular level between exercise-induced signaling events and those induced by insulin trying to elucidate the mechanisms by which exercise can improve muscle insulin sensitivity.

    Our approaches to gain such insights include invasive studies of healthy and diseased subjects in combination with mechanistic studies using animal models - including various transgenic approaches. We seek to adapt state of art technologies in our research - including multiomics technologies. Further, we seek to gain insight at the single muscle fiber level using both biochemistry and imaging techniques. In collaborations with various clinical laboratories and pharma industries we aim to translate our findings into relevance for patients and society.

    Active research areas includes:

    Molecular muscle adaptations induced by exercise leading to improved insulin sensitivity

    Exercise induced exosomes/proteins/metabolits release from skeletal muscle  

    Role of AMPK and mTOR in metabolic regulation during and in recovery of exercise

    Role of TBC1D4/TBC1D1 in metabolic regulation by insulin and exercise

    Mechanisms allowing muscle glycogen supercompensation after exercise

    Development of pre-clinical human muscle model

    Undervisnings- og vejledningsområder

    • Muskelstofskifte
    • Fysisk aktivitet
    • Sundhed
    • Træning
    • Molekylær signalering
    • Insulinfølsomhed

    ID: 10716