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Carboxylesterase 1 gene duplication and mRNA expression in adipose tissue are linked to obesity and metabolic function

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Martin Friedrichsen, Pernille Poulsen, Jørgen Wojtaszewski, Peter Riis Hansen, Allan Vaag, Henrik Berg Rasmussen

CONTEXT AND AIMS: Carboxylesterase 1 (CES1) appears to play an important role in the control of the metabolism of triglycerides and cholesterol in adipocytes and other cell types including hepatocytes. Therefore, it is relevant to gain insights into the genetic versus non-genetic mechanisms involved in the control of mRNA expression. Here, we investigated mRNA expression level in adipose tissue and its association with measures of adiposity and metabolic function in a population of elderly twins. Furthermore, the heritability of mRNA expression level in adipose tissue and the effect of gene duplication were assessed.
OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind8
Tidsskriftsnummer2
Sider (fra-til)e56861
Antal sider7
ISSN1932-6203
DOI
StatusUdgivet - 2013

Bibliografisk note

CURIS 2013 NEXS 052

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