Women produce fewer but triglyceride-richer very low-density lipoproteins than men

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Women produce fewer but triglyceride-richer very low-density lipoproteins than men. / Magkos, Faidon; Patterson, Bruce W; Mohammed, B Selma; Klein, Samuel; Mittendorfer, Bettina.

I: Journal of Clinical Endocrinology and Metabolism, Bind 92, Nr. 4, 2007, s. 1311-1318.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Magkos, F, Patterson, BW, Mohammed, BS, Klein, S & Mittendorfer, B 2007, 'Women produce fewer but triglyceride-richer very low-density lipoproteins than men', Journal of Clinical Endocrinology and Metabolism, bind 92, nr. 4, s. 1311-1318. https://doi.org/10.1210/jc.2006-2215

APA

Magkos, F., Patterson, B. W., Mohammed, B. S., Klein, S., & Mittendorfer, B. (2007). Women produce fewer but triglyceride-richer very low-density lipoproteins than men. Journal of Clinical Endocrinology and Metabolism, 92(4), 1311-1318. https://doi.org/10.1210/jc.2006-2215

Vancouver

Magkos F, Patterson BW, Mohammed BS, Klein S, Mittendorfer B. Women produce fewer but triglyceride-richer very low-density lipoproteins than men. Journal of Clinical Endocrinology and Metabolism. 2007;92(4):1311-1318. https://doi.org/10.1210/jc.2006-2215

Author

Magkos, Faidon ; Patterson, Bruce W ; Mohammed, B Selma ; Klein, Samuel ; Mittendorfer, Bettina. / Women produce fewer but triglyceride-richer very low-density lipoproteins than men. I: Journal of Clinical Endocrinology and Metabolism. 2007 ; Bind 92, Nr. 4. s. 1311-1318.

Bibtex

@article{e54d7c3a3dfd43e7974d2af9fbd7b122,
title = "Women produce fewer but triglyceride-richer very low-density lipoproteins than men",
abstract = "Context: Very low-density lipoproteins (VLDL) are a major risk factor for cardiovascular disease. The concentrations of VLDL particles and VLDL-triglyceride (TG) in plasma are lower in women than men, but the mechanisms responsible for these differences are unclear.Objective: The objective of the study was to investigate the effects of sex on VLDL-TG and VLDL-apolipoprotein B-100 (apoB-100) metabolism.Experimental design and main outcome measures: We measured basal VLDL-TG and VLDL-apoB-100 kinetics by using stable isotope labeled tracers.Setting / paticipants: Twenty-six healthy, lean subjects (13 men, aged 29+/-5 yr; 13 women, aged 28+/-6 yr) were studied in the General Clinical Research Center at Washington University School of Medicine.Results: VLDL-TG and VLDL-apoB-100 concentrations were less in women than men (P<0.05). The secretion rate of VLDL-TG was approximately 70% greater (P<0.05), whereas the secretion rate of VLDL-apoB-100 (i.e. VLDL particles) was approximately 20% less (P<0.05) in women than men. The molar ratio of VLDL-TG and VLDL-apoB-100 secretion rates was therefore more than double (P<0.05) in women than men. VLDL-TG plasma clearance rate was approximately 70% greater in women than men (P<0.05), whereas VLDL-apoB-100 plasma clearance rate was not different between sexes. However, VLDL-TG and VLDL-apoB-100 mean residence times in plasma were both shorter (by 45 and 25%, respectively; P<0.05) in women than men.Conclusions: Increased VLDL-TG plasma clearance is responsible for lower VLDL-TG concentration, whereas decreased VLDL-apoB-100 secretion rate, combined with shorter VLDL-apoB-100 residence time in plasma, is responsible for lower VLDL-apoB-100 concentration in women than men. The greater molar ratio of VLDL-TG and VLDL-apoB-100 secretion rates suggests that the liver in women secretes fewer but TG-richer VLDL particles than the liver in men.",
keywords = "Adipose Tissue/anatomy & histology, Adult, Apolipoprotein B-100/blood, Body Height, Body Mass Index, Body Weight, Fatty Acids, Nonesterified/blood, Female, Hormones/blood, Humans, Insulin/blood, Lipoproteins, LDL/blood, Male, Sex Characteristics, Triglycerides/blood",
author = "Faidon Magkos and Patterson, {Bruce W} and Mohammed, {B Selma} and Samuel Klein and Bettina Mittendorfer",
note = "(Ekstern)",
year = "2007",
doi = "10.1210/jc.2006-2215",
language = "English",
volume = "92",
pages = "1311--1318",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Women produce fewer but triglyceride-richer very low-density lipoproteins than men

AU - Magkos, Faidon

AU - Patterson, Bruce W

AU - Mohammed, B Selma

AU - Klein, Samuel

AU - Mittendorfer, Bettina

N1 - (Ekstern)

PY - 2007

Y1 - 2007

N2 - Context: Very low-density lipoproteins (VLDL) are a major risk factor for cardiovascular disease. The concentrations of VLDL particles and VLDL-triglyceride (TG) in plasma are lower in women than men, but the mechanisms responsible for these differences are unclear.Objective: The objective of the study was to investigate the effects of sex on VLDL-TG and VLDL-apolipoprotein B-100 (apoB-100) metabolism.Experimental design and main outcome measures: We measured basal VLDL-TG and VLDL-apoB-100 kinetics by using stable isotope labeled tracers.Setting / paticipants: Twenty-six healthy, lean subjects (13 men, aged 29+/-5 yr; 13 women, aged 28+/-6 yr) were studied in the General Clinical Research Center at Washington University School of Medicine.Results: VLDL-TG and VLDL-apoB-100 concentrations were less in women than men (P<0.05). The secretion rate of VLDL-TG was approximately 70% greater (P<0.05), whereas the secretion rate of VLDL-apoB-100 (i.e. VLDL particles) was approximately 20% less (P<0.05) in women than men. The molar ratio of VLDL-TG and VLDL-apoB-100 secretion rates was therefore more than double (P<0.05) in women than men. VLDL-TG plasma clearance rate was approximately 70% greater in women than men (P<0.05), whereas VLDL-apoB-100 plasma clearance rate was not different between sexes. However, VLDL-TG and VLDL-apoB-100 mean residence times in plasma were both shorter (by 45 and 25%, respectively; P<0.05) in women than men.Conclusions: Increased VLDL-TG plasma clearance is responsible for lower VLDL-TG concentration, whereas decreased VLDL-apoB-100 secretion rate, combined with shorter VLDL-apoB-100 residence time in plasma, is responsible for lower VLDL-apoB-100 concentration in women than men. The greater molar ratio of VLDL-TG and VLDL-apoB-100 secretion rates suggests that the liver in women secretes fewer but TG-richer VLDL particles than the liver in men.

AB - Context: Very low-density lipoproteins (VLDL) are a major risk factor for cardiovascular disease. The concentrations of VLDL particles and VLDL-triglyceride (TG) in plasma are lower in women than men, but the mechanisms responsible for these differences are unclear.Objective: The objective of the study was to investigate the effects of sex on VLDL-TG and VLDL-apolipoprotein B-100 (apoB-100) metabolism.Experimental design and main outcome measures: We measured basal VLDL-TG and VLDL-apoB-100 kinetics by using stable isotope labeled tracers.Setting / paticipants: Twenty-six healthy, lean subjects (13 men, aged 29+/-5 yr; 13 women, aged 28+/-6 yr) were studied in the General Clinical Research Center at Washington University School of Medicine.Results: VLDL-TG and VLDL-apoB-100 concentrations were less in women than men (P<0.05). The secretion rate of VLDL-TG was approximately 70% greater (P<0.05), whereas the secretion rate of VLDL-apoB-100 (i.e. VLDL particles) was approximately 20% less (P<0.05) in women than men. The molar ratio of VLDL-TG and VLDL-apoB-100 secretion rates was therefore more than double (P<0.05) in women than men. VLDL-TG plasma clearance rate was approximately 70% greater in women than men (P<0.05), whereas VLDL-apoB-100 plasma clearance rate was not different between sexes. However, VLDL-TG and VLDL-apoB-100 mean residence times in plasma were both shorter (by 45 and 25%, respectively; P<0.05) in women than men.Conclusions: Increased VLDL-TG plasma clearance is responsible for lower VLDL-TG concentration, whereas decreased VLDL-apoB-100 secretion rate, combined with shorter VLDL-apoB-100 residence time in plasma, is responsible for lower VLDL-apoB-100 concentration in women than men. The greater molar ratio of VLDL-TG and VLDL-apoB-100 secretion rates suggests that the liver in women secretes fewer but TG-richer VLDL particles than the liver in men.

KW - Adipose Tissue/anatomy & histology

KW - Adult

KW - Apolipoprotein B-100/blood

KW - Body Height

KW - Body Mass Index

KW - Body Weight

KW - Fatty Acids, Nonesterified/blood

KW - Female

KW - Hormones/blood

KW - Humans

KW - Insulin/blood

KW - Lipoproteins, LDL/blood

KW - Male

KW - Sex Characteristics

KW - Triglycerides/blood

U2 - 10.1210/jc.2006-2215

DO - 10.1210/jc.2006-2215

M3 - Journal article

C2 - 17264179

VL - 92

SP - 1311

EP - 1318

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 4

ER -

ID: 297154222