The effect of passive movement training on angiogenic factors and capillary growth in human skeletal muscle

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Standard

The effect of passive movement training on angiogenic factors and capillary growth in human skeletal muscle. / Høier, Birgitte; Rufener, Nora; Bojsen-Møller, Jens; Bangsbo, Jens; Hellsten, Ylva.

I: Journal of Physiology, Bind 588, Nr. 19, 2010, s. 3833-3845.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Høier, B, Rufener, N, Bojsen-Møller, J, Bangsbo, J & Hellsten, Y 2010, 'The effect of passive movement training on angiogenic factors and capillary growth in human skeletal muscle', Journal of Physiology, bind 588, nr. 19, s. 3833-3845. https://doi.org/10.1113/jphysiol.2010.190439

APA

Høier, B., Rufener, N., Bojsen-Møller, J., Bangsbo, J., & Hellsten, Y. (2010). The effect of passive movement training on angiogenic factors and capillary growth in human skeletal muscle. Journal of Physiology, 588(19), 3833-3845. https://doi.org/10.1113/jphysiol.2010.190439

Vancouver

Høier B, Rufener N, Bojsen-Møller J, Bangsbo J, Hellsten Y. The effect of passive movement training on angiogenic factors and capillary growth in human skeletal muscle. Journal of Physiology. 2010;588(19):3833-3845. https://doi.org/10.1113/jphysiol.2010.190439

Author

Høier, Birgitte ; Rufener, Nora ; Bojsen-Møller, Jens ; Bangsbo, Jens ; Hellsten, Ylva. / The effect of passive movement training on angiogenic factors and capillary growth in human skeletal muscle. I: Journal of Physiology. 2010 ; Bind 588, Nr. 19. s. 3833-3845.

Bibtex

@article{4efd4c10c7c211df825b000ea68e967b,
title = "The effect of passive movement training on angiogenic factors and capillary growth in human skeletal muscle",
abstract = "Abstract The effect of a period of passive movement training on angiogenic factors and capillarization in skeletal muscle was examined. Seven young males were subjected to passive training for 90 min, four times/week in a motor-driven knee extensor device that extended one knee passively at 80 cycles/min. The other leg was used as control. Muscle biopsies were obtained from m. v. lateralis of both legs before as well as after 2 and 4 weeks of training. After the training period, passive movement and active exercise were performed with both legs and muscle interstitial fluid was sampled from microdialysis probes in the thigh. After 2 wks of training there was a 2-fold higher level of Ki-67 positive cells, co-localized with endothelial cells, in the passively trained leg which was paralleled by an increase in the number of capillaries around a fibre (P < 0.05). Capillary density was higher than pre-training at 4 weeks of training (P < 0.05). The training induced an increase in the mRNA level of endothelial nitric oxide synthase (eNOS), the angiopoietin receptor Tie-2 and matrix metalloproteinase (MMP)-9 in the passively trained leg and MMP-2 and Tissue inhibitor of MMP (TIMP)-1 mRNA were elevated in both legs. Acute passive movement increased (P < 0.05) muscle interstitial VEGF levels 4-6 -fold above rest and the proliferative effect, determined in vitro, of the muscle interstitial fluid ~16-fold compared to perfusate. These increases were similar for active exercise. The results demonstrate that a period of passive movement promotes endothelial cell proliferation, angiogenic factors and initiates capillarization in skeletal muscle. Key words: angiogenesis, passive movement, shear stress, passive stretch, skeletal muscle, microdialysis.",
author = "Birgitte H{\o}ier and Nora Rufener and Jens Bojsen-M{\o}ller and Jens Bangsbo and Ylva Hellsten",
note = "CURIS 2010 5200 107",
year = "2010",
doi = "10.1113/jphysiol.2010.190439",
language = "English",
volume = "588",
pages = "3833--3845",
journal = "The Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",
number = "19",

}

RIS

TY - JOUR

T1 - The effect of passive movement training on angiogenic factors and capillary growth in human skeletal muscle

AU - Høier, Birgitte

AU - Rufener, Nora

AU - Bojsen-Møller, Jens

AU - Bangsbo, Jens

AU - Hellsten, Ylva

N1 - CURIS 2010 5200 107

PY - 2010

Y1 - 2010

N2 - Abstract The effect of a period of passive movement training on angiogenic factors and capillarization in skeletal muscle was examined. Seven young males were subjected to passive training for 90 min, four times/week in a motor-driven knee extensor device that extended one knee passively at 80 cycles/min. The other leg was used as control. Muscle biopsies were obtained from m. v. lateralis of both legs before as well as after 2 and 4 weeks of training. After the training period, passive movement and active exercise were performed with both legs and muscle interstitial fluid was sampled from microdialysis probes in the thigh. After 2 wks of training there was a 2-fold higher level of Ki-67 positive cells, co-localized with endothelial cells, in the passively trained leg which was paralleled by an increase in the number of capillaries around a fibre (P < 0.05). Capillary density was higher than pre-training at 4 weeks of training (P < 0.05). The training induced an increase in the mRNA level of endothelial nitric oxide synthase (eNOS), the angiopoietin receptor Tie-2 and matrix metalloproteinase (MMP)-9 in the passively trained leg and MMP-2 and Tissue inhibitor of MMP (TIMP)-1 mRNA were elevated in both legs. Acute passive movement increased (P < 0.05) muscle interstitial VEGF levels 4-6 -fold above rest and the proliferative effect, determined in vitro, of the muscle interstitial fluid ~16-fold compared to perfusate. These increases were similar for active exercise. The results demonstrate that a period of passive movement promotes endothelial cell proliferation, angiogenic factors and initiates capillarization in skeletal muscle. Key words: angiogenesis, passive movement, shear stress, passive stretch, skeletal muscle, microdialysis.

AB - Abstract The effect of a period of passive movement training on angiogenic factors and capillarization in skeletal muscle was examined. Seven young males were subjected to passive training for 90 min, four times/week in a motor-driven knee extensor device that extended one knee passively at 80 cycles/min. The other leg was used as control. Muscle biopsies were obtained from m. v. lateralis of both legs before as well as after 2 and 4 weeks of training. After the training period, passive movement and active exercise were performed with both legs and muscle interstitial fluid was sampled from microdialysis probes in the thigh. After 2 wks of training there was a 2-fold higher level of Ki-67 positive cells, co-localized with endothelial cells, in the passively trained leg which was paralleled by an increase in the number of capillaries around a fibre (P < 0.05). Capillary density was higher than pre-training at 4 weeks of training (P < 0.05). The training induced an increase in the mRNA level of endothelial nitric oxide synthase (eNOS), the angiopoietin receptor Tie-2 and matrix metalloproteinase (MMP)-9 in the passively trained leg and MMP-2 and Tissue inhibitor of MMP (TIMP)-1 mRNA were elevated in both legs. Acute passive movement increased (P < 0.05) muscle interstitial VEGF levels 4-6 -fold above rest and the proliferative effect, determined in vitro, of the muscle interstitial fluid ~16-fold compared to perfusate. These increases were similar for active exercise. The results demonstrate that a period of passive movement promotes endothelial cell proliferation, angiogenic factors and initiates capillarization in skeletal muscle. Key words: angiogenesis, passive movement, shear stress, passive stretch, skeletal muscle, microdialysis.

U2 - 10.1113/jphysiol.2010.190439

DO - 10.1113/jphysiol.2010.190439

M3 - Journal article

C2 - 20693292

VL - 588

SP - 3833

EP - 3845

JO - The Journal of Physiology

JF - The Journal of Physiology

SN - 0022-3751

IS - 19

ER -

ID: 22195042