Skeletal muscle glucose uptake during exercise: How is it regulated?

Publikation: Bidrag til tidsskriftReviewForskning

The increase in skeletal muscle glucose uptake during exercise results from a coordinated increase in rates of glucose delivery (higher capillary perfusion), surface membrane glucose transport, and intracellular substrate flux through glycolysis. The mechanism behind the movement of GLUT4 to surface membranes and the subsequent increase in transport by muscle contractions is largely unresolved, but it is likely to occur through intracellular signaling involving Ca2+-calmodulin-dependent protein kinase, 5'-AMP-activated protein kinase, and possibly protein kinase C.
Udgave nummer4
Sider (fra-til)260-270
Antal sider11
StatusUdgivet - 2005

Bibliografisk note

PUF 2005 5200 037

ID: 90675