Resveratrol modulates the angiogenic response to exercise training in skeletal muscle of aged men

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Resveratrol modulates the angiogenic response to exercise training in skeletal muscle of aged men. / Gliemann Hybholt, Lasse; Olesen, Jesper; Biensø, Rasmus S; Schmidt, Jakob Friis; Åkerström, Thorbjörn; Nyberg, Michael Permin; Lindqvist, Anna; Bangsbo, Jens; Hellsten, Ylva.

I: American Journal of Physiology: Heart and Circulatory Physiology, Bind 307, Nr. 8, 2014, s. H1111-H1119.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Gliemann Hybholt, L, Olesen, J, Biensø, RS, Schmidt, JF, Åkerström, T, Nyberg, MP, Lindqvist, A, Bangsbo, J & Hellsten, Y 2014, 'Resveratrol modulates the angiogenic response to exercise training in skeletal muscle of aged men', American Journal of Physiology: Heart and Circulatory Physiology, bind 307, nr. 8, s. H1111-H1119. https://doi.org/10.1152/ajpheart.00168.2014

APA

Gliemann Hybholt, L., Olesen, J., Biensø, R. S., Schmidt, J. F., Åkerström, T., Nyberg, M. P., Lindqvist, A., Bangsbo, J., & Hellsten, Y. (2014). Resveratrol modulates the angiogenic response to exercise training in skeletal muscle of aged men. American Journal of Physiology: Heart and Circulatory Physiology, 307(8), H1111-H1119. https://doi.org/10.1152/ajpheart.00168.2014

Vancouver

Gliemann Hybholt L, Olesen J, Biensø RS, Schmidt JF, Åkerström T, Nyberg MP o.a. Resveratrol modulates the angiogenic response to exercise training in skeletal muscle of aged men. American Journal of Physiology: Heart and Circulatory Physiology. 2014;307(8):H1111-H1119. https://doi.org/10.1152/ajpheart.00168.2014

Author

Gliemann Hybholt, Lasse ; Olesen, Jesper ; Biensø, Rasmus S ; Schmidt, Jakob Friis ; Åkerström, Thorbjörn ; Nyberg, Michael Permin ; Lindqvist, Anna ; Bangsbo, Jens ; Hellsten, Ylva. / Resveratrol modulates the angiogenic response to exercise training in skeletal muscle of aged men. I: American Journal of Physiology: Heart and Circulatory Physiology. 2014 ; Bind 307, Nr. 8. s. H1111-H1119.

Bibtex

@article{a11772eaa53c445faf77c208dbebf37b,
title = "Resveratrol modulates the angiogenic response to exercise training in skeletal muscle of aged men",
abstract = "Aim: The polyphenol resveratrol has in animal studies been shown to influence several pathways of importance for angiogenesis in skeletal muscle. The aim was to examine the angiogenic effect of resveratrol supplementation with parallel exercise training in aged men. Methods: Forty-three healthy physically inactive aged men (65±1 years) were divided into A) a training group that conducted 8 weeks of intense exercise training where half of the subjects received a daily intake of either 250 mg trans resveratrol (n=14) and the other half received placebo (n=13); and B) a non-training group that received either 250 mg trans resveratrol (n=9) or placebo (n=7). Results: The group that trained with placebo showed a ~20% increase in capillary to fiber (C:F) ratio, an increase in the muscle protein expression of vascular endothelial growth factor (VEGF), VEGF receptor-2, and tissue inhibitor of matrix metalloproteinase (TIMP-1) but unaltered thrombospodin-1 (TSP-1) levels. Muscle interstitial VEGF and TSP-1 protein levels were unchanged after the training period. The group training with resveratrol supplementation did not show an increase in C:F ratio or an increase in muscle VEGF protein. Muscle TIMP-1 protein levels were lower in the training and resveratrol group than in the training and placebo group. Both training groups showed an increase in Forkhead box O1 protein. In the non-training groups, TIMP-1 protein was lower in the resveratrol group than the placebo group after 8 weeks. Conclusion: These data show that exercise training has a strong angiogenic effect whereas resveratrol supplementation may limit basal and training-induced angiogenesis.",
author = "{Gliemann Hybholt}, Lasse and Jesper Olesen and Biens{\o}, {Rasmus S} and Schmidt, {Jakob Friis} and Thorbj{\"o}rn {\AA}kerstr{\"o}m and Nyberg, {Michael Permin} and Anna Lindqvist and Jens Bangsbo and Ylva Hellsten",
note = "CURIS 2014 NEXS 242",
year = "2014",
doi = "10.1152/ajpheart.00168.2014",
language = "English",
volume = "307",
pages = "H1111--H1119",
journal = "American Journal of Physiology: Heart and Circulatory Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "8",

}

RIS

TY - JOUR

T1 - Resveratrol modulates the angiogenic response to exercise training in skeletal muscle of aged men

AU - Gliemann Hybholt, Lasse

AU - Olesen, Jesper

AU - Biensø, Rasmus S

AU - Schmidt, Jakob Friis

AU - Åkerström, Thorbjörn

AU - Nyberg, Michael Permin

AU - Lindqvist, Anna

AU - Bangsbo, Jens

AU - Hellsten, Ylva

N1 - CURIS 2014 NEXS 242

PY - 2014

Y1 - 2014

N2 - Aim: The polyphenol resveratrol has in animal studies been shown to influence several pathways of importance for angiogenesis in skeletal muscle. The aim was to examine the angiogenic effect of resveratrol supplementation with parallel exercise training in aged men. Methods: Forty-three healthy physically inactive aged men (65±1 years) were divided into A) a training group that conducted 8 weeks of intense exercise training where half of the subjects received a daily intake of either 250 mg trans resveratrol (n=14) and the other half received placebo (n=13); and B) a non-training group that received either 250 mg trans resveratrol (n=9) or placebo (n=7). Results: The group that trained with placebo showed a ~20% increase in capillary to fiber (C:F) ratio, an increase in the muscle protein expression of vascular endothelial growth factor (VEGF), VEGF receptor-2, and tissue inhibitor of matrix metalloproteinase (TIMP-1) but unaltered thrombospodin-1 (TSP-1) levels. Muscle interstitial VEGF and TSP-1 protein levels were unchanged after the training period. The group training with resveratrol supplementation did not show an increase in C:F ratio or an increase in muscle VEGF protein. Muscle TIMP-1 protein levels were lower in the training and resveratrol group than in the training and placebo group. Both training groups showed an increase in Forkhead box O1 protein. In the non-training groups, TIMP-1 protein was lower in the resveratrol group than the placebo group after 8 weeks. Conclusion: These data show that exercise training has a strong angiogenic effect whereas resveratrol supplementation may limit basal and training-induced angiogenesis.

AB - Aim: The polyphenol resveratrol has in animal studies been shown to influence several pathways of importance for angiogenesis in skeletal muscle. The aim was to examine the angiogenic effect of resveratrol supplementation with parallel exercise training in aged men. Methods: Forty-three healthy physically inactive aged men (65±1 years) were divided into A) a training group that conducted 8 weeks of intense exercise training where half of the subjects received a daily intake of either 250 mg trans resveratrol (n=14) and the other half received placebo (n=13); and B) a non-training group that received either 250 mg trans resveratrol (n=9) or placebo (n=7). Results: The group that trained with placebo showed a ~20% increase in capillary to fiber (C:F) ratio, an increase in the muscle protein expression of vascular endothelial growth factor (VEGF), VEGF receptor-2, and tissue inhibitor of matrix metalloproteinase (TIMP-1) but unaltered thrombospodin-1 (TSP-1) levels. Muscle interstitial VEGF and TSP-1 protein levels were unchanged after the training period. The group training with resveratrol supplementation did not show an increase in C:F ratio or an increase in muscle VEGF protein. Muscle TIMP-1 protein levels were lower in the training and resveratrol group than in the training and placebo group. Both training groups showed an increase in Forkhead box O1 protein. In the non-training groups, TIMP-1 protein was lower in the resveratrol group than the placebo group after 8 weeks. Conclusion: These data show that exercise training has a strong angiogenic effect whereas resveratrol supplementation may limit basal and training-induced angiogenesis.

U2 - 10.1152/ajpheart.00168.2014

DO - 10.1152/ajpheart.00168.2014

M3 - Journal article

C2 - 25128170

VL - 307

SP - H1111-H1119

JO - American Journal of Physiology: Heart and Circulatory Physiology

JF - American Journal of Physiology: Heart and Circulatory Physiology

SN - 0363-6135

IS - 8

ER -

ID: 120840985