Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

Publikation: Bidrag til tidsskriftReview

Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle.
OriginalsprogEngelsk
TidsskriftCellular Signalling
Vol/bind23
Udgave nummer10
Sider (fra-til)1546-1554
Antal sider9
ISSN0898-6568
DOI
StatusUdgivet - 2011

Bibliografisk note

CURIS 2011 5200 065

ID: 33716512