Possible interactions between dietary fibres and 5-aminosalicylic acid [corrected]

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Standard

Possible interactions between dietary fibres and 5-aminosalicylic acid [corrected]. / Henriksen, Camilla; Hansen, Steen Honoré; Nordgaard-Lassen, Inge; Andersen, Jens Rikardt; Madsen, Pia Lisbeth.

I: Therapeutic Advances in Gastroenterology, Bind 3, Nr. 1, 01.2010, s. 5-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Henriksen, C, Hansen, SH, Nordgaard-Lassen, I, Andersen, JR & Madsen, PL 2010, 'Possible interactions between dietary fibres and 5-aminosalicylic acid [corrected]', Therapeutic Advances in Gastroenterology, bind 3, nr. 1, s. 5-9. https://doi.org/10.1177/1756283X09347810

APA

Henriksen, C., Hansen, S. H., Nordgaard-Lassen, I., Andersen, J. R., & Madsen, P. L. (2010). Possible interactions between dietary fibres and 5-aminosalicylic acid [corrected]. Therapeutic Advances in Gastroenterology, 3(1), 5-9. https://doi.org/10.1177/1756283X09347810

Vancouver

Henriksen C, Hansen SH, Nordgaard-Lassen I, Andersen JR, Madsen PL. Possible interactions between dietary fibres and 5-aminosalicylic acid [corrected]. Therapeutic Advances in Gastroenterology. 2010 jan;3(1):5-9. https://doi.org/10.1177/1756283X09347810

Author

Henriksen, Camilla ; Hansen, Steen Honoré ; Nordgaard-Lassen, Inge ; Andersen, Jens Rikardt ; Madsen, Pia Lisbeth. / Possible interactions between dietary fibres and 5-aminosalicylic acid [corrected]. I: Therapeutic Advances in Gastroenterology. 2010 ; Bind 3, Nr. 1. s. 5-9.

Bibtex

@article{c91e178c49b24703b83394dc3fe7ad0f,
title = "Possible interactions between dietary fibres and 5-aminosalicylic acid [corrected]",
abstract = "BACKGROUND: Potentially, a binding of 5-aminosalicylic acid (5-ASA) to dietary fibres could reduce the systemic absorption and increase the intraluminal amount [corrected]. The purposes of the study were to investigate if: (1) dietary fibres can bind 5-ASA in vitro, and (2) consumption of dietary fibres is related to disease activity in patients with ulcerative colitis (UC) treated with 5-ASA.METHODS: In vitro: 15 g of Ispaghula Husk, wheat bran, citrus-pectin, or wheat flour were incubated in a 37°C buffered solutions of 5-ASA (1 g/l) for 3 hours at pH 6 and 7. The concentrations of 5-ASA were determined before and after the incubation using HPLC. In vivo: patients with UC were interviewed two to three times during 6 months. The fibre consumption was estimated and related to the disease activity (CAI, CRP, Faecal-calprotectin) and quality of life (IBDQ).RESULTS: In vitro: 5-ASA was bound to Ispaghula Husk (5.3-10.0 mg/g) and wheat bran (4.6-5.5 mg/g), and to a minor degree to citrus-pectin. No differences were found in relation to pH. In vivo: 29 patients completed the scheduled interviews. No significant changes in fibre consumption were observed over time; however, patients consuming a diet high in fibre (>20 g/day) had significantly lower CRP (p <0.01) and faecal-calprotectin (p <0.01) than those consuming less fibre (<20 g/dg).CONCLUSIONS: Patients with a high intake of fibre had a lower disease activity than those with low intake. Ispaghula Husk bound 5-ASA in vitro, independent of pH. The effect might be clinically relevant in patients with UC treated with 5-ASA.",
author = "Camilla Henriksen and Hansen, {Steen Honor{\'e}} and Inge Nordgaard-Lassen and Andersen, {Jens Rikardt} and Madsen, {Pia Lisbeth}",
year = "2010",
month = jan,
doi = "10.1177/1756283X09347810",
language = "English",
volume = "3",
pages = "5--9",
journal = "Therapeutic Advances in Gastroenterology",
issn = "1756-283X",
publisher = "SAGE Publications",
number = "1",

}

RIS

TY - JOUR

T1 - Possible interactions between dietary fibres and 5-aminosalicylic acid [corrected]

AU - Henriksen, Camilla

AU - Hansen, Steen Honoré

AU - Nordgaard-Lassen, Inge

AU - Andersen, Jens Rikardt

AU - Madsen, Pia Lisbeth

PY - 2010/1

Y1 - 2010/1

N2 - BACKGROUND: Potentially, a binding of 5-aminosalicylic acid (5-ASA) to dietary fibres could reduce the systemic absorption and increase the intraluminal amount [corrected]. The purposes of the study were to investigate if: (1) dietary fibres can bind 5-ASA in vitro, and (2) consumption of dietary fibres is related to disease activity in patients with ulcerative colitis (UC) treated with 5-ASA.METHODS: In vitro: 15 g of Ispaghula Husk, wheat bran, citrus-pectin, or wheat flour were incubated in a 37°C buffered solutions of 5-ASA (1 g/l) for 3 hours at pH 6 and 7. The concentrations of 5-ASA were determined before and after the incubation using HPLC. In vivo: patients with UC were interviewed two to three times during 6 months. The fibre consumption was estimated and related to the disease activity (CAI, CRP, Faecal-calprotectin) and quality of life (IBDQ).RESULTS: In vitro: 5-ASA was bound to Ispaghula Husk (5.3-10.0 mg/g) and wheat bran (4.6-5.5 mg/g), and to a minor degree to citrus-pectin. No differences were found in relation to pH. In vivo: 29 patients completed the scheduled interviews. No significant changes in fibre consumption were observed over time; however, patients consuming a diet high in fibre (>20 g/day) had significantly lower CRP (p <0.01) and faecal-calprotectin (p <0.01) than those consuming less fibre (<20 g/dg).CONCLUSIONS: Patients with a high intake of fibre had a lower disease activity than those with low intake. Ispaghula Husk bound 5-ASA in vitro, independent of pH. The effect might be clinically relevant in patients with UC treated with 5-ASA.

AB - BACKGROUND: Potentially, a binding of 5-aminosalicylic acid (5-ASA) to dietary fibres could reduce the systemic absorption and increase the intraluminal amount [corrected]. The purposes of the study were to investigate if: (1) dietary fibres can bind 5-ASA in vitro, and (2) consumption of dietary fibres is related to disease activity in patients with ulcerative colitis (UC) treated with 5-ASA.METHODS: In vitro: 15 g of Ispaghula Husk, wheat bran, citrus-pectin, or wheat flour were incubated in a 37°C buffered solutions of 5-ASA (1 g/l) for 3 hours at pH 6 and 7. The concentrations of 5-ASA were determined before and after the incubation using HPLC. In vivo: patients with UC were interviewed two to three times during 6 months. The fibre consumption was estimated and related to the disease activity (CAI, CRP, Faecal-calprotectin) and quality of life (IBDQ).RESULTS: In vitro: 5-ASA was bound to Ispaghula Husk (5.3-10.0 mg/g) and wheat bran (4.6-5.5 mg/g), and to a minor degree to citrus-pectin. No differences were found in relation to pH. In vivo: 29 patients completed the scheduled interviews. No significant changes in fibre consumption were observed over time; however, patients consuming a diet high in fibre (>20 g/day) had significantly lower CRP (p <0.01) and faecal-calprotectin (p <0.01) than those consuming less fibre (<20 g/dg).CONCLUSIONS: Patients with a high intake of fibre had a lower disease activity than those with low intake. Ispaghula Husk bound 5-ASA in vitro, independent of pH. The effect might be clinically relevant in patients with UC treated with 5-ASA.

U2 - 10.1177/1756283X09347810

DO - 10.1177/1756283X09347810

M3 - Journal article

C2 - 21180585

VL - 3

SP - 5

EP - 9

JO - Therapeutic Advances in Gastroenterology

JF - Therapeutic Advances in Gastroenterology

SN - 1756-283X

IS - 1

ER -

ID: 161726042