Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake. / Meslier, Victoria; Laiola, Manolo; Roager, Henrik Munch; De Filippis, Francesca; Roume, Hugo; Quinquis, Benoit; Giacco, Rosalba; Mennella, Ilario; Ferracane, Rosalia; Pons, Nicolas; Pasolli, Edoardo; Rivellese, Angela; Dragsted, Lars Ove; Vitaglione, Paola; Ehrlich, Stanislav Dusko; Ercolini, Danilo.

I: Gut, Bind 69, Nr. 7, 2020, s. 1258-1268.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Meslier, V, Laiola, M, Roager, HM, De Filippis, F, Roume, H, Quinquis, B, Giacco, R, Mennella, I, Ferracane, R, Pons, N, Pasolli, E, Rivellese, A, Dragsted, LO, Vitaglione, P, Ehrlich, SD & Ercolini, D 2020, 'Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake', Gut, bind 69, nr. 7, s. 1258-1268. https://doi.org/10.1136/gutjnl-2019-320438

APA

Meslier, V., Laiola, M., Roager, H. M., De Filippis, F., Roume, H., Quinquis, B., Giacco, R., Mennella, I., Ferracane, R., Pons, N., Pasolli, E., Rivellese, A., Dragsted, L. O., Vitaglione, P., Ehrlich, S. D., & Ercolini, D. (2020). Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake. Gut, 69(7), 1258-1268. https://doi.org/10.1136/gutjnl-2019-320438

Vancouver

Meslier V, Laiola M, Roager HM, De Filippis F, Roume H, Quinquis B o.a. Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake. Gut. 2020;69(7):1258-1268. https://doi.org/10.1136/gutjnl-2019-320438

Author

Meslier, Victoria ; Laiola, Manolo ; Roager, Henrik Munch ; De Filippis, Francesca ; Roume, Hugo ; Quinquis, Benoit ; Giacco, Rosalba ; Mennella, Ilario ; Ferracane, Rosalia ; Pons, Nicolas ; Pasolli, Edoardo ; Rivellese, Angela ; Dragsted, Lars Ove ; Vitaglione, Paola ; Ehrlich, Stanislav Dusko ; Ercolini, Danilo. / Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake. I: Gut. 2020 ; Bind 69, Nr. 7. s. 1258-1268.

Bibtex

@article{a56958b4775e4a3381aadc8eb7a08ff4,

title = "Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake",

abstract = "Objectives: This study aimed to explore the effects of an isocaloric Mediterranean diet (MD) intervention on metabolic health, gut microbiome and systemic metabolome in subjects with lifestyle risk factors for metabolic disease.Design: Eighty-two healthy overweight and obese subjects with a habitually low intake of fruit and vegetables and a sedentary lifestyle participated in a parallel 8-week randomised controlled trial. Forty-three participants consumed an MD tailored to their habitual energy intakes (MedD), and 39 maintained their regular diets (ConD). Dietary adherence, metabolic parameters, gut microbiome and systemic metabolome were monitored over the study period.Results: Increased MD adherence in the MedD group successfully reprogrammed subjects' intake of fibre and animal proteins. Compliance was confirmed by lowered levels of carnitine in plasma and urine. Significant reductions in plasma cholesterol (primary outcome) and faecal bile acids occurred in the MedD compared with the ConD group. Shotgun metagenomics showed gut microbiome changes that reflected individual MD adherence and increase in gene richness in participants who reduced systemic inflammation over the intervention. The MD intervention led to increased levels of the fibre-degrading Faecalibacterium prausnitzii and of genes for microbial carbohydrate degradation linked to butyrate metabolism. The dietary changes in the MedD group led to increased urinary urolithins, faecal bile acid degradation and insulin sensitivity that co-varied with specific microbial taxa.Conclusion: Switching subjects to an MD while maintaining their energy intake reduced their blood cholesterol and caused multiple changes in their microbiome and metabolome that are relevant in future strategies for the improvement of metabolic health.",

author = "Victoria Meslier and Manolo Laiola and Roager, {Henrik Munch} and {De Filippis}, Francesca and Hugo Roume and Benoit Quinquis and Rosalba Giacco and Ilario Mennella and Rosalia Ferracane and Nicolas Pons and Edoardo Pasolli and Angela Rivellese and Dragsted, {Lars Ove} and Paola Vitaglione and Ehrlich, {Stanislav Dusko} and Danilo Ercolini",

note = "{\textcopyright} Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",

year = "2020",

doi = "10.1136/gutjnl-2019-320438",

language = "English",

volume = "69",

pages = "1258--1268",

journal = "Gut",

issn = "0017-5749",

publisher = "B M J Group",

number = "7",

}

RIS

TY - JOUR

T1 - Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake

AU - Meslier, Victoria

AU - Laiola, Manolo

AU - Roager, Henrik Munch

AU - De Filippis, Francesca

AU - Roume, Hugo

AU - Quinquis, Benoit

AU - Giacco, Rosalba

AU - Mennella, Ilario

AU - Ferracane, Rosalia

AU - Pons, Nicolas

AU - Pasolli, Edoardo

AU - Rivellese, Angela

AU - Dragsted, Lars Ove

AU - Vitaglione, Paola

AU - Ehrlich, Stanislav Dusko

AU - Ercolini, Danilo

PY - 2020

Y1 - 2020

N2 - Objectives: This study aimed to explore the effects of an isocaloric Mediterranean diet (MD) intervention on metabolic health, gut microbiome and systemic metabolome in subjects with lifestyle risk factors for metabolic disease.Design: Eighty-two healthy overweight and obese subjects with a habitually low intake of fruit and vegetables and a sedentary lifestyle participated in a parallel 8-week randomised controlled trial. Forty-three participants consumed an MD tailored to their habitual energy intakes (MedD), and 39 maintained their regular diets (ConD). Dietary adherence, metabolic parameters, gut microbiome and systemic metabolome were monitored over the study period.Results: Increased MD adherence in the MedD group successfully reprogrammed subjects' intake of fibre and animal proteins. Compliance was confirmed by lowered levels of carnitine in plasma and urine. Significant reductions in plasma cholesterol (primary outcome) and faecal bile acids occurred in the MedD compared with the ConD group. Shotgun metagenomics showed gut microbiome changes that reflected individual MD adherence and increase in gene richness in participants who reduced systemic inflammation over the intervention. The MD intervention led to increased levels of the fibre-degrading Faecalibacterium prausnitzii and of genes for microbial carbohydrate degradation linked to butyrate metabolism. The dietary changes in the MedD group led to increased urinary urolithins, faecal bile acid degradation and insulin sensitivity that co-varied with specific microbial taxa.Conclusion: Switching subjects to an MD while maintaining their energy intake reduced their blood cholesterol and caused multiple changes in their microbiome and metabolome that are relevant in future strategies for the improvement of metabolic health.

AB - Objectives: This study aimed to explore the effects of an isocaloric Mediterranean diet (MD) intervention on metabolic health, gut microbiome and systemic metabolome in subjects with lifestyle risk factors for metabolic disease.Design: Eighty-two healthy overweight and obese subjects with a habitually low intake of fruit and vegetables and a sedentary lifestyle participated in a parallel 8-week randomised controlled trial. Forty-three participants consumed an MD tailored to their habitual energy intakes (MedD), and 39 maintained their regular diets (ConD). Dietary adherence, metabolic parameters, gut microbiome and systemic metabolome were monitored over the study period.Results: Increased MD adherence in the MedD group successfully reprogrammed subjects' intake of fibre and animal proteins. Compliance was confirmed by lowered levels of carnitine in plasma and urine. Significant reductions in plasma cholesterol (primary outcome) and faecal bile acids occurred in the MedD compared with the ConD group. Shotgun metagenomics showed gut microbiome changes that reflected individual MD adherence and increase in gene richness in participants who reduced systemic inflammation over the intervention. The MD intervention led to increased levels of the fibre-degrading Faecalibacterium prausnitzii and of genes for microbial carbohydrate degradation linked to butyrate metabolism. The dietary changes in the MedD group led to increased urinary urolithins, faecal bile acid degradation and insulin sensitivity that co-varied with specific microbial taxa.Conclusion: Switching subjects to an MD while maintaining their energy intake reduced their blood cholesterol and caused multiple changes in their microbiome and metabolome that are relevant in future strategies for the improvement of metabolic health.

U2 - 10.1136/gutjnl-2019-320438

DO - 10.1136/gutjnl-2019-320438

M3 - Journal article

C2 - 32075887

VL - 69

SP - 1258

EP - 1268

JO - Gut

JF - Gut

SN - 0017-5749

IS - 7

ER -

ID: 237656717

Institut for Idræt og Ernæring