Meat consumption, N-acetyl transferase 1 and 2 polymorphism and risk of breast cancer in Danish postmenopausal women

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Standard

Meat consumption, N-acetyl transferase 1 and 2 polymorphism and risk of breast cancer in Danish postmenopausal women. / Egeberg, Rikke; Olsen, Anja; Autrup, Herman; Christensen, Jane; Stripp, Connie; Tetens, Inge; Overvad, Kim; Tjønneland, Anne.

I: European Journal of Cancer Prevention, Bind 17, Nr. 1, 2008, s. 39-47.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Egeberg, R, Olsen, A, Autrup, H, Christensen, J, Stripp, C, Tetens, I, Overvad, K & Tjønneland, A 2008, 'Meat consumption, N-acetyl transferase 1 and 2 polymorphism and risk of breast cancer in Danish postmenopausal women', European Journal of Cancer Prevention, bind 17, nr. 1, s. 39-47. https://doi.org/10.1097/CEJ.0b013e32809b4cdd

APA

Egeberg, R., Olsen, A., Autrup, H., Christensen, J., Stripp, C., Tetens, I., Overvad, K., & Tjønneland, A. (2008). Meat consumption, N-acetyl transferase 1 and 2 polymorphism and risk of breast cancer in Danish postmenopausal women. European Journal of Cancer Prevention, 17(1), 39-47. https://doi.org/10.1097/CEJ.0b013e32809b4cdd

Vancouver

Egeberg R, Olsen A, Autrup H, Christensen J, Stripp C, Tetens I o.a. Meat consumption, N-acetyl transferase 1 and 2 polymorphism and risk of breast cancer in Danish postmenopausal women. European Journal of Cancer Prevention. 2008;17(1):39-47. https://doi.org/10.1097/CEJ.0b013e32809b4cdd

Author

Egeberg, Rikke ; Olsen, Anja ; Autrup, Herman ; Christensen, Jane ; Stripp, Connie ; Tetens, Inge ; Overvad, Kim ; Tjønneland, Anne. / Meat consumption, N-acetyl transferase 1 and 2 polymorphism and risk of breast cancer in Danish postmenopausal women. I: European Journal of Cancer Prevention. 2008 ; Bind 17, Nr. 1. s. 39-47.

Bibtex

@article{be3fbc7251184888882ed62c3cb6237e,
title = "Meat consumption, N-acetyl transferase 1 and 2 polymorphism and risk of breast cancer in Danish postmenopausal women",
abstract = "The aim of this study was to investigate whether polymorphisms in N-acetyl transferase 1 and 2 modify the association between meat consumption and risk of breast cancer. A nested case-control study was conducted among 24 697 postmenopausal women included in the 'Diet, Cancer and Health' cohort study (1993-2000). Three hundred and seventy-eight breast cancer cases were identified and matched to 378 controls. The incidence rate ratio (95% confidence interval) for breast cancer was 1.09 (1.02-1.17) for total meat, 1.15 (1.01-1.31) for red meat and 1.23 (1.04-1.45) for processed meat per 25 g daily increment in intake. Compared with slow acetylators, the IRR (95% confidence interval) among fast N-acetyl transferase 1 acetylators was 1.43 (1.03-1.99) and 1.13 (0.83-1.54) among intermediate/fast N-acetyl transferase 2 acetylators. Interaction analyses revealed that the positive associations between total meat intake and red meat intake and breast cancer risk were confined to intermediate/fast N-acetyl transferase 2 acetylators (Pinteraction = 0.03 and 0.04). Our findings support an association between meat consumption and breast cancer risk and that N-acetyl transferase 2 polymorphism has a modifying effect on the association, indicating that the association is confined to only genetically susceptible women.",
keywords = "Arylamine N-Acetyltransferase, Breast Neoplasms, Case-Control Studies, Cohort Studies, Denmark, Female, Genotype, Humans, Isoenzymes, Meat, Middle Aged, Polymorphism, Genetic, Postmenopause, Risk Factors, Comparative Study, Breast cancer, Meat consumption, NAT polymorphism, Prospective cohort study",
author = "Rikke Egeberg and Anja Olsen and Herman Autrup and Jane Christensen and Connie Stripp and Inge Tetens and Kim Overvad and Anne Tj{\o}nneland",
year = "2008",
doi = "10.1097/CEJ.0b013e32809b4cdd",
language = "English",
volume = "17",
pages = "39--47",
journal = "European Journal of Cancer Prevention",
issn = "0959-8278",
publisher = "Lippincott Williams & Wilkins, Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Meat consumption, N-acetyl transferase 1 and 2 polymorphism and risk of breast cancer in Danish postmenopausal women

AU - Egeberg, Rikke

AU - Olsen, Anja

AU - Autrup, Herman

AU - Christensen, Jane

AU - Stripp, Connie

AU - Tetens, Inge

AU - Overvad, Kim

AU - Tjønneland, Anne

PY - 2008

Y1 - 2008

N2 - The aim of this study was to investigate whether polymorphisms in N-acetyl transferase 1 and 2 modify the association between meat consumption and risk of breast cancer. A nested case-control study was conducted among 24 697 postmenopausal women included in the 'Diet, Cancer and Health' cohort study (1993-2000). Three hundred and seventy-eight breast cancer cases were identified and matched to 378 controls. The incidence rate ratio (95% confidence interval) for breast cancer was 1.09 (1.02-1.17) for total meat, 1.15 (1.01-1.31) for red meat and 1.23 (1.04-1.45) for processed meat per 25 g daily increment in intake. Compared with slow acetylators, the IRR (95% confidence interval) among fast N-acetyl transferase 1 acetylators was 1.43 (1.03-1.99) and 1.13 (0.83-1.54) among intermediate/fast N-acetyl transferase 2 acetylators. Interaction analyses revealed that the positive associations between total meat intake and red meat intake and breast cancer risk were confined to intermediate/fast N-acetyl transferase 2 acetylators (Pinteraction = 0.03 and 0.04). Our findings support an association between meat consumption and breast cancer risk and that N-acetyl transferase 2 polymorphism has a modifying effect on the association, indicating that the association is confined to only genetically susceptible women.

AB - The aim of this study was to investigate whether polymorphisms in N-acetyl transferase 1 and 2 modify the association between meat consumption and risk of breast cancer. A nested case-control study was conducted among 24 697 postmenopausal women included in the 'Diet, Cancer and Health' cohort study (1993-2000). Three hundred and seventy-eight breast cancer cases were identified and matched to 378 controls. The incidence rate ratio (95% confidence interval) for breast cancer was 1.09 (1.02-1.17) for total meat, 1.15 (1.01-1.31) for red meat and 1.23 (1.04-1.45) for processed meat per 25 g daily increment in intake. Compared with slow acetylators, the IRR (95% confidence interval) among fast N-acetyl transferase 1 acetylators was 1.43 (1.03-1.99) and 1.13 (0.83-1.54) among intermediate/fast N-acetyl transferase 2 acetylators. Interaction analyses revealed that the positive associations between total meat intake and red meat intake and breast cancer risk were confined to intermediate/fast N-acetyl transferase 2 acetylators (Pinteraction = 0.03 and 0.04). Our findings support an association between meat consumption and breast cancer risk and that N-acetyl transferase 2 polymorphism has a modifying effect on the association, indicating that the association is confined to only genetically susceptible women.

KW - Arylamine N-Acetyltransferase

KW - Breast Neoplasms

KW - Case-Control Studies

KW - Cohort Studies

KW - Denmark

KW - Female

KW - Genotype

KW - Humans

KW - Isoenzymes

KW - Meat

KW - Middle Aged

KW - Polymorphism, Genetic

KW - Postmenopause

KW - Risk Factors

KW - Comparative Study

KW - Breast cancer

KW - Meat consumption

KW - NAT polymorphism

KW - Prospective cohort study

U2 - 10.1097/CEJ.0b013e32809b4cdd

DO - 10.1097/CEJ.0b013e32809b4cdd

M3 - Journal article

C2 - 18090909

VL - 17

SP - 39

EP - 47

JO - European Journal of Cancer Prevention

JF - European Journal of Cancer Prevention

SN - 0959-8278

IS - 1

ER -

ID: 184389995