Leg oxygen uptake in the initial phase of intense exercise is slowed by a marked reduction in oxygen delivery
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Leg oxygen uptake in the initial phase of intense exercise is slowed by a marked reduction in oxygen delivery. / Christensen, Peter Møller; Nyberg, Michael Permin; Mortensen, Stefan Peter; Nielsen, Jens Jung; Secher, Niels H.; Damsgaard, Rasmus; Hellsten, Ylva; Bangsbo, Jens.
I: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Bind 305, Nr. 3, 2013, s. R313-R321.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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TY - JOUR
T1 - Leg oxygen uptake in the initial phase of intense exercise is slowed by a marked reduction in oxygen delivery
AU - Christensen, Peter Møller
AU - Nyberg, Michael Permin
AU - Mortensen, Stefan Peter
AU - Nielsen, Jens Jung
AU - Secher, Niels H.
AU - Damsgaard, Rasmus
AU - Hellsten, Ylva
AU - Bangsbo, Jens
N1 - CURIS 2013 NEXS 124
PY - 2013
Y1 - 2013
N2 - The present study examined if a marked reduction in oxygen delivery, unlike findings with moderate intensity exercise, would slow leg oxygen uptake (VO2) kinetics during intense exercise (86±3% of incremental test peak power). Seven healthy males (26±1 years, mean±SEM) performed one-legged knee-extensor exercise (60±3 W) for 4 min in a control setting (CON) and with arterial infusion of L-NMMA and indomethacin in the working leg to reduce blood flow by inhibiting formation of nitric oxide and prostanoids (double blockade; DB). In DB leg blood flow (LBF) and oxygen delivery during the first minute of exercise were 25-50% lower (P
AB - The present study examined if a marked reduction in oxygen delivery, unlike findings with moderate intensity exercise, would slow leg oxygen uptake (VO2) kinetics during intense exercise (86±3% of incremental test peak power). Seven healthy males (26±1 years, mean±SEM) performed one-legged knee-extensor exercise (60±3 W) for 4 min in a control setting (CON) and with arterial infusion of L-NMMA and indomethacin in the working leg to reduce blood flow by inhibiting formation of nitric oxide and prostanoids (double blockade; DB). In DB leg blood flow (LBF) and oxygen delivery during the first minute of exercise were 25-50% lower (P
U2 - 10.1152/ajpregu.00048.2013
DO - 10.1152/ajpregu.00048.2013
M3 - Journal article
C2 - 23720134
VL - 305
SP - R313-R321
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6119
IS - 3
ER -
ID: 46386153