Hepatic Insulin Clearance in Regulation of Systemic Insulin Concentrations—Role of Carbohydrate and Energy Availability
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Hepatic Insulin Clearance in Regulation of Systemic Insulin Concentrations—Role of Carbohydrate and Energy Availability. / Bojsen-Møller, Kirstine N; Lundsgaard, Anne-Marie; Madsbad, Sten; Kiens, Bente; Holst, Jens Juul.
I: Diabetes, Bind 67, Nr. 11, 11.2018, s. 2129-2136.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Hepatic Insulin Clearance in Regulation of Systemic Insulin Concentrations—Role of Carbohydrate and Energy Availability
AU - Bojsen-Møller, Kirstine N
AU - Lundsgaard, Anne-Marie
AU - Madsbad, Sten
AU - Kiens, Bente
AU - Holst, Jens Juul
N1 - CURIS 2018 NEXS 368
PY - 2018/11
Y1 - 2018/11
N2 - Hyperinsulinemia is the hallmark of insulin resistance in obesity, and the relative importance of insulin clearance, insulin resistance, and insulin hypersecretion has been widely debated. On the basis of recent experimental evidence, we summarize existing evidence to suggest hepatic insulin clearance as a major and immediate regulator of systemic insulin concentrations responding within days to altered dietary energy and, in particular, carbohydrate intake. Hepatic insulin clearance seems to be closely associated with opposite alterations in hepatic lipid content and glucose production, providing a potential mechanistic link to hepatic insulin sensitivity. The molecular regulation of insulin clearance in the liver is likely to involve changes in insulin binding and receptor internalization in response to the dietary alterations, the molecular mechanisms of which await further research.
AB - Hyperinsulinemia is the hallmark of insulin resistance in obesity, and the relative importance of insulin clearance, insulin resistance, and insulin hypersecretion has been widely debated. On the basis of recent experimental evidence, we summarize existing evidence to suggest hepatic insulin clearance as a major and immediate regulator of systemic insulin concentrations responding within days to altered dietary energy and, in particular, carbohydrate intake. Hepatic insulin clearance seems to be closely associated with opposite alterations in hepatic lipid content and glucose production, providing a potential mechanistic link to hepatic insulin sensitivity. The molecular regulation of insulin clearance in the liver is likely to involve changes in insulin binding and receptor internalization in response to the dietary alterations, the molecular mechanisms of which await further research.
KW - Animals
KW - Carbohydrate Metabolism/physiology
KW - Energy Metabolism/physiology
KW - Humans
KW - Insulin/blood
KW - Liver/metabolism
U2 - 10.2337/db18-0539
DO - 10.2337/db18-0539
M3 - Journal article
C2 - 30348819
AN - SCOPUS:85055143689
VL - 67
SP - 2129
EP - 2136
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - 11
ER -
ID: 204306481