Gender differences in fasting and postprandial metabolic traits predictive of subclinical atherosclerosis in an asymptomatic Chinese population
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Gender differences in fasting and postprandial metabolic traits predictive of subclinical atherosclerosis in an asymptomatic Chinese population. / Loh, Xinpeng; Sun, Lijuan; Allen, John Carson; Goh, Hui Jen; Kong, Siew Ching; Huang, Weiting; Ding, Cherlyn; Bosco, Nabil; Egli, Leonie; Actis-Goretta, Lucas; Magkos, Faidon; Arigoni, Fabrizio; Yeo, Khung Keong; Leow, Melvin Khee-Shing.
I: Scientific Reports, Bind 12, 16890, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Gender differences in fasting and postprandial metabolic traits predictive of subclinical atherosclerosis in an asymptomatic Chinese population
AU - Loh, Xinpeng
AU - Sun, Lijuan
AU - Allen, John Carson
AU - Goh, Hui Jen
AU - Kong, Siew Ching
AU - Huang, Weiting
AU - Ding, Cherlyn
AU - Bosco, Nabil
AU - Egli, Leonie
AU - Actis-Goretta, Lucas
AU - Magkos, Faidon
AU - Arigoni, Fabrizio
AU - Yeo, Khung Keong
AU - Leow, Melvin Khee-Shing
N1 - © 2022. The Author(s).
PY - 2022
Y1 - 2022
N2 - The prediction utility of Framingham Risk Score in populations with low conventional cardiovascular risk burden is limited, particularly among women. Gender-specific markers to predict cardiovascular risk in overtly healthy people are lacking. In this study we hypothesize that postprandial responses triggered by a high-calorie meal test differ by gender in their ability to triage asymptomatic subjects into those with and without subclinical atherosclerosis. A total of 101 healthy Chinese subjects (46 females, 55 males) at low risk of coronary heart disease completed the study. Subjects underwent cardiovascular imaging and postprandial blood phenotyping after consuming a standardized macronutrient meal. Prediction models were developed using logistic regression and subsequently subjected to cross-validation to obtain a de-optimized receiver operating characteristic (ROC) curve. Distinctive gender differences in postprandial trajectories of glucose, lipids and inflammatory markers were observed. We used gender-specific association with different combinations of postprandial predictors to develop 2 models for predicting risk of subclinical atherosclerosis in males (ROC AUC = 0.7867, 95% CI 0.6567, 0.9166) and females (ROC AUC = 0.9161, 95% CI 0.8340, 0.9982) respectively. We report novel postprandial models for predicting subclinical atherosclerosis in apparently healthy Asian subjects using a gender-specific approach, complementing the conventional Framingham Risk Score.Clinical Trial Registration: The trial was registered at clinicaltrials.gov as NCT03531879.
AB - The prediction utility of Framingham Risk Score in populations with low conventional cardiovascular risk burden is limited, particularly among women. Gender-specific markers to predict cardiovascular risk in overtly healthy people are lacking. In this study we hypothesize that postprandial responses triggered by a high-calorie meal test differ by gender in their ability to triage asymptomatic subjects into those with and without subclinical atherosclerosis. A total of 101 healthy Chinese subjects (46 females, 55 males) at low risk of coronary heart disease completed the study. Subjects underwent cardiovascular imaging and postprandial blood phenotyping after consuming a standardized macronutrient meal. Prediction models were developed using logistic regression and subsequently subjected to cross-validation to obtain a de-optimized receiver operating characteristic (ROC) curve. Distinctive gender differences in postprandial trajectories of glucose, lipids and inflammatory markers were observed. We used gender-specific association with different combinations of postprandial predictors to develop 2 models for predicting risk of subclinical atherosclerosis in males (ROC AUC = 0.7867, 95% CI 0.6567, 0.9166) and females (ROC AUC = 0.9161, 95% CI 0.8340, 0.9982) respectively. We report novel postprandial models for predicting subclinical atherosclerosis in apparently healthy Asian subjects using a gender-specific approach, complementing the conventional Framingham Risk Score.Clinical Trial Registration: The trial was registered at clinicaltrials.gov as NCT03531879.
KW - Atherosclerosis
KW - China
KW - Fasting
KW - Female
KW - Glucose
KW - Humans
KW - Lipids
KW - Male
KW - Postprandial period
KW - Risk factors
KW - Sex factors
U2 - 10.1038/s41598-022-20714-6
DO - 10.1038/s41598-022-20714-6
M3 - Journal article
C2 - 36207366
VL - 12
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 16890
ER -
ID: 322947042