Exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humans

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Standard

Exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humans. / De Bock, K.; Richter, Erik A.; Russell, A.P.; Eijnde, Bert O.; Derave, W.; Ramaekers, M.; Koninckx, E.; Léger, B.; Verhaeghe, J.; Hespel, P.

I: Journal of Physiology, Bind 564, Nr. 2, 2005, s. 649-660.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

De Bock, K, Richter, EA, Russell, AP, Eijnde, BO, Derave, W, Ramaekers, M, Koninckx, E, Léger, B, Verhaeghe, J & Hespel, P 2005, 'Exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humans', Journal of Physiology, bind 564, nr. 2, s. 649-660. https://doi.org/10.1113/jphysiol.2005.083170

APA

De Bock, K., Richter, E. A., Russell, A. P., Eijnde, B. O., Derave, W., Ramaekers, M., ... Hespel, P. (2005). Exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humans. Journal of Physiology, 564(2), 649-660. https://doi.org/10.1113/jphysiol.2005.083170

Vancouver

De Bock K, Richter EA, Russell AP, Eijnde BO, Derave W, Ramaekers M o.a. Exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humans. Journal of Physiology. 2005;564(2):649-660. https://doi.org/10.1113/jphysiol.2005.083170

Author

De Bock, K. ; Richter, Erik A. ; Russell, A.P. ; Eijnde, Bert O. ; Derave, W. ; Ramaekers, M. ; Koninckx, E. ; Léger, B. ; Verhaeghe, J. ; Hespel, P. / Exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humans. I: Journal of Physiology. 2005 ; Bind 564, Nr. 2. s. 649-660.

Bibtex

@article{15c9f890a55611dbbee902004c4f4f50,
title = "Exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humans",
abstract = "The effects were compared of exercise in the fasted state and exercise with a high rate of carbohydrate intake on intramyocellular triglyceride (IMTG) and glycogen content of human muscle. Using a randomized crossover study design, nine young healthy volunteers participated in two experimental sessions with an interval of 3 weeks. In each session subjects performed 2 h of constant-load bicycle exercise (~75{\%} VO2,max), followed by 4 h of controlled recovery. On one occasion they exercised after an overnight fast (F), and on the other (CHO) they received carbohydrates before (~150 g) and during (1 g (kg bw)-1 h-1) exercise. In both conditions, subjects ingested 5 g carbohydrates per kg body weight during recovery. Fibre type-specific relative IMTG content was determined by Oil red O staining in needle biopsies from m. vastus lateralis before, immediately after and 4 h after exercise. During F but not during CHO, the exercise bout decreased IMTG content in type I fibres from 18 ± 2{\%} to 6 ± 2{\%} (P = 0.007) area lipid staining. Conversely, during recovery, IMTG in type I fibres decreased from 15 ± 2{\%} to 10 ± 2{\%} in CHO, but did not change in F. Neither exercise nor recovery changed IMTG in type IIa fibres in any experimental condition. Exercise-induced net glycogen breakdown was similar in F and CHO. However, compared with CHO (11.0 ± 7.8 mmol kg-1 h-1), mean rate of postexercise muscle glycogen resynthesis was 3-fold greater in F (32.9 ± 2.7 mmol kg-1 h-1, P = 0.01). Furthermore, oral glucose loading during recovery increased plasma insulin markedly more in F (+46.80 µU ml-1) than in CHO (+14.63 µU ml-1, P = 0.02). We conclude that IMTG breakdown during prolonged submaximal exercise in the fasted state takes place predominantly in type I fibres and that this breakdown is prevented in the CHO-fed state. Furthermore, facilitated glucose-induced insulin secretion may contribute to enhanced muscle glycogen resynthesis following exercise in the fasted state.",
author = "{De Bock}, K. and Richter, {Erik A.} and A.P. Russell and Eijnde, {Bert O.} and W. Derave and M. Ramaekers and E. Koninckx and B. L{\'e}ger and J. Verhaeghe and P. Hespel",
note = "PUF 2005 5200 026",
year = "2005",
doi = "10.1113/jphysiol.2005.083170",
language = "English",
volume = "564",
pages = "649--660",
journal = "The Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humans

AU - De Bock, K.

AU - Richter, Erik A.

AU - Russell, A.P.

AU - Eijnde, Bert O.

AU - Derave, W.

AU - Ramaekers, M.

AU - Koninckx, E.

AU - Léger, B.

AU - Verhaeghe, J.

AU - Hespel, P.

N1 - PUF 2005 5200 026

PY - 2005

Y1 - 2005

N2 - The effects were compared of exercise in the fasted state and exercise with a high rate of carbohydrate intake on intramyocellular triglyceride (IMTG) and glycogen content of human muscle. Using a randomized crossover study design, nine young healthy volunteers participated in two experimental sessions with an interval of 3 weeks. In each session subjects performed 2 h of constant-load bicycle exercise (~75% VO2,max), followed by 4 h of controlled recovery. On one occasion they exercised after an overnight fast (F), and on the other (CHO) they received carbohydrates before (~150 g) and during (1 g (kg bw)-1 h-1) exercise. In both conditions, subjects ingested 5 g carbohydrates per kg body weight during recovery. Fibre type-specific relative IMTG content was determined by Oil red O staining in needle biopsies from m. vastus lateralis before, immediately after and 4 h after exercise. During F but not during CHO, the exercise bout decreased IMTG content in type I fibres from 18 ± 2% to 6 ± 2% (P = 0.007) area lipid staining. Conversely, during recovery, IMTG in type I fibres decreased from 15 ± 2% to 10 ± 2% in CHO, but did not change in F. Neither exercise nor recovery changed IMTG in type IIa fibres in any experimental condition. Exercise-induced net glycogen breakdown was similar in F and CHO. However, compared with CHO (11.0 ± 7.8 mmol kg-1 h-1), mean rate of postexercise muscle glycogen resynthesis was 3-fold greater in F (32.9 ± 2.7 mmol kg-1 h-1, P = 0.01). Furthermore, oral glucose loading during recovery increased plasma insulin markedly more in F (+46.80 µU ml-1) than in CHO (+14.63 µU ml-1, P = 0.02). We conclude that IMTG breakdown during prolonged submaximal exercise in the fasted state takes place predominantly in type I fibres and that this breakdown is prevented in the CHO-fed state. Furthermore, facilitated glucose-induced insulin secretion may contribute to enhanced muscle glycogen resynthesis following exercise in the fasted state.

AB - The effects were compared of exercise in the fasted state and exercise with a high rate of carbohydrate intake on intramyocellular triglyceride (IMTG) and glycogen content of human muscle. Using a randomized crossover study design, nine young healthy volunteers participated in two experimental sessions with an interval of 3 weeks. In each session subjects performed 2 h of constant-load bicycle exercise (~75% VO2,max), followed by 4 h of controlled recovery. On one occasion they exercised after an overnight fast (F), and on the other (CHO) they received carbohydrates before (~150 g) and during (1 g (kg bw)-1 h-1) exercise. In both conditions, subjects ingested 5 g carbohydrates per kg body weight during recovery. Fibre type-specific relative IMTG content was determined by Oil red O staining in needle biopsies from m. vastus lateralis before, immediately after and 4 h after exercise. During F but not during CHO, the exercise bout decreased IMTG content in type I fibres from 18 ± 2% to 6 ± 2% (P = 0.007) area lipid staining. Conversely, during recovery, IMTG in type I fibres decreased from 15 ± 2% to 10 ± 2% in CHO, but did not change in F. Neither exercise nor recovery changed IMTG in type IIa fibres in any experimental condition. Exercise-induced net glycogen breakdown was similar in F and CHO. However, compared with CHO (11.0 ± 7.8 mmol kg-1 h-1), mean rate of postexercise muscle glycogen resynthesis was 3-fold greater in F (32.9 ± 2.7 mmol kg-1 h-1, P = 0.01). Furthermore, oral glucose loading during recovery increased plasma insulin markedly more in F (+46.80 µU ml-1) than in CHO (+14.63 µU ml-1, P = 0.02). We conclude that IMTG breakdown during prolonged submaximal exercise in the fasted state takes place predominantly in type I fibres and that this breakdown is prevented in the CHO-fed state. Furthermore, facilitated glucose-induced insulin secretion may contribute to enhanced muscle glycogen resynthesis following exercise in the fasted state.

U2 - 10.1113/jphysiol.2005.083170

DO - 10.1113/jphysiol.2005.083170

M3 - Journal article

C2 - 15705646

VL - 564

SP - 649

EP - 660

JO - The Journal of Physiology

JF - The Journal of Physiology

SN - 0022-3751

IS - 2

ER -

ID: 91397