Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness

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Standard

Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness. / Bozek, Katarzyna; Wei, Yuning; Yan, Zheng; Liu, Xiling; Xiong, Jieyi; Sugimoto, Masahiro; Tomita, Masaru; Pääbo, Svante; Pieszek, Raik; Sherwood, Chet C; Hof, Patrick R; Ely, John J; Steinhauser, Dirk; Willmitzer, Lothar; Bangsbo, Jens; Hansson, Ola; Call, Josep; Giavalisco, Patrick; Khaitovich, Philipp.

I: P L o S Biology, Bind 12, Nr. 5, e1001871, 2014.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Bozek, K, Wei, Y, Yan, Z, Liu, X, Xiong, J, Sugimoto, M, Tomita, M, Pääbo, S, Pieszek, R, Sherwood, CC, Hof, PR, Ely, JJ, Steinhauser, D, Willmitzer, L, Bangsbo, J, Hansson, O, Call, J, Giavalisco, P & Khaitovich, P 2014, 'Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness', P L o S Biology, bind 12, nr. 5, e1001871. https://doi.org/10.1371/journal.pbio.1001871

APA

Bozek, K., Wei, Y., Yan, Z., Liu, X., Xiong, J., Sugimoto, M., ... Khaitovich, P. (2014). Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness. P L o S Biology, 12(5), [e1001871]. https://doi.org/10.1371/journal.pbio.1001871

Vancouver

Bozek K, Wei Y, Yan Z, Liu X, Xiong J, Sugimoto M o.a. Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness. P L o S Biology. 2014;12(5). e1001871. https://doi.org/10.1371/journal.pbio.1001871

Author

Bozek, Katarzyna ; Wei, Yuning ; Yan, Zheng ; Liu, Xiling ; Xiong, Jieyi ; Sugimoto, Masahiro ; Tomita, Masaru ; Pääbo, Svante ; Pieszek, Raik ; Sherwood, Chet C ; Hof, Patrick R ; Ely, John J ; Steinhauser, Dirk ; Willmitzer, Lothar ; Bangsbo, Jens ; Hansson, Ola ; Call, Josep ; Giavalisco, Patrick ; Khaitovich, Philipp. / Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness. I: P L o S Biology. 2014 ; Bind 12, Nr. 5.

Bibtex

@article{e3d19e61d0a640768c082050d9ff54bc,
title = "Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness",
abstract = "Metabolite concentrations reflect the physiological states of tissues and cells. However, the role of metabolic changes in species evolution is currently unknown. Here, we present a study of metabolome evolution conducted in three brain regions and two non-neural tissues from humans, chimpanzees, macaque monkeys, and mice based on over 10,000 hydrophilic compounds. While chimpanzee, macaque, and mouse metabolomes diverge following the genetic distances among species, we detect remarkable acceleration of metabolome evolution in human prefrontal cortex and skeletal muscle affecting neural and energy metabolism pathways. These metabolic changes could not be attributed to environmental conditions and were confirmed against the expression of their corresponding enzymes. We further conducted muscle strength tests in humans, chimpanzees, and macaques. The results suggest that, while humans are characterized by superior cognition, their muscular performance might be markedly inferior to that of chimpanzees and macaque monkeys.",
author = "Katarzyna Bozek and Yuning Wei and Zheng Yan and Xiling Liu and Jieyi Xiong and Masahiro Sugimoto and Masaru Tomita and Svante P{\"a}{\"a}bo and Raik Pieszek and Sherwood, {Chet C} and Hof, {Patrick R} and Ely, {John J} and Dirk Steinhauser and Lothar Willmitzer and Jens Bangsbo and Ola Hansson and Josep Call and Patrick Giavalisco and Philipp Khaitovich",
note = "CURIS 2014 NEXS 159",
year = "2014",
doi = "10.1371/journal.pbio.1001871",
language = "English",
volume = "12",
journal = "P L o S Biology",
issn = "1544-9173",
publisher = "Public Library of Science",
number = "5",

}

RIS

TY - JOUR

T1 - Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness

AU - Bozek, Katarzyna

AU - Wei, Yuning

AU - Yan, Zheng

AU - Liu, Xiling

AU - Xiong, Jieyi

AU - Sugimoto, Masahiro

AU - Tomita, Masaru

AU - Pääbo, Svante

AU - Pieszek, Raik

AU - Sherwood, Chet C

AU - Hof, Patrick R

AU - Ely, John J

AU - Steinhauser, Dirk

AU - Willmitzer, Lothar

AU - Bangsbo, Jens

AU - Hansson, Ola

AU - Call, Josep

AU - Giavalisco, Patrick

AU - Khaitovich, Philipp

N1 - CURIS 2014 NEXS 159

PY - 2014

Y1 - 2014

N2 - Metabolite concentrations reflect the physiological states of tissues and cells. However, the role of metabolic changes in species evolution is currently unknown. Here, we present a study of metabolome evolution conducted in three brain regions and two non-neural tissues from humans, chimpanzees, macaque monkeys, and mice based on over 10,000 hydrophilic compounds. While chimpanzee, macaque, and mouse metabolomes diverge following the genetic distances among species, we detect remarkable acceleration of metabolome evolution in human prefrontal cortex and skeletal muscle affecting neural and energy metabolism pathways. These metabolic changes could not be attributed to environmental conditions and were confirmed against the expression of their corresponding enzymes. We further conducted muscle strength tests in humans, chimpanzees, and macaques. The results suggest that, while humans are characterized by superior cognition, their muscular performance might be markedly inferior to that of chimpanzees and macaque monkeys.

AB - Metabolite concentrations reflect the physiological states of tissues and cells. However, the role of metabolic changes in species evolution is currently unknown. Here, we present a study of metabolome evolution conducted in three brain regions and two non-neural tissues from humans, chimpanzees, macaque monkeys, and mice based on over 10,000 hydrophilic compounds. While chimpanzee, macaque, and mouse metabolomes diverge following the genetic distances among species, we detect remarkable acceleration of metabolome evolution in human prefrontal cortex and skeletal muscle affecting neural and energy metabolism pathways. These metabolic changes could not be attributed to environmental conditions and were confirmed against the expression of their corresponding enzymes. We further conducted muscle strength tests in humans, chimpanzees, and macaques. The results suggest that, while humans are characterized by superior cognition, their muscular performance might be markedly inferior to that of chimpanzees and macaque monkeys.

U2 - 10.1371/journal.pbio.1001871

DO - 10.1371/journal.pbio.1001871

M3 - Journal article

C2 - 24866127

VL - 12

JO - P L o S Biology

JF - P L o S Biology

SN - 1544-9173

IS - 5

M1 - e1001871

ER -

ID: 113244513